FB2024_03 , released June 25, 2024
Allele: Dmel\Rap1R-1
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General Information
Symbol
Dmel\Rap1R-1
Species
D. melanogaster
Name
FlyBase ID
FBal0014168
Feature type
allele
Associated gene
Dmel\Rap1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

neomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    neomorphic allele - genetic evidence

    (Hariharan et al., 1991)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: F157L. Nucleotide substitution: C?G.

    (Hariharan et al., 1991)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:1,860,741..1,860,741 [-]
    Nucleotide change:

    C1860741G

    Amino acid change:

    F157L | Rap1-PA; F157L | Rap1-PB; F157L | Rap1-PC

    Reported amino acid change:

    F157L

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Hariharan et al., 1991)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Rough eye phenotype.

        (Asha et al., 1999)

        Roughened external eye morphology, internally most facets are missing R7 and some are missing outer cells. Analysis of mosaic facets reveals a strong requirement of R in R7 and a weaker requirement in R6.

        (Li et al., 1997)

        Heterozygotes have rough eyes due to disruption of the normal ommatidial array. Most ommatidia have the R7 cell missing, others an outer photoreceptor missing, ommatidia may be fused and their orientation with respect to each other is random. Secondary pigment cells are also missing. Homozygotes have rough eyes and reduced viability. R1/Df(3L)R-E heterozygotes have a rougher eye phenotype than R1 heterozygotes.

        (Hariharan et al., 1991)

        Eyes of R/+ rough, have some large dark facets. Photoreceptor cell 7 frequently absent (Carthew). Male genitalia frequently rotated and male sometimes sterile; viability about 80% wild type. wings spread. Thorax short; acrostichal hairs deranged, some missing; eyes small. homozygous female-fertile. RK1. homozygous semi-lethal

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Rap1[+]/Rap1R-1 is an enhancer of visible | adult stage phenotype of Scer\GAL4A9, ShrmA.UAS

        (Hildebrand et al., 2021)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        Rap1R-1 has phenotype, enhanceable by dap2

        (de Nooij et al., 1996)

        Rap1R-1 has phenotype, enhanceable by dap3

        (de Nooij et al., 1996)
        NOT suppressed by
        Statement
        Reference

        Rap1R-1 has phenotype, non-suppressible by su(Hw)2

        (Lindsley and Grell, 1968)
        Enhancer of
        Statement
        Reference

        Rap1[+]/Rap1R-1 is an enhancer of wing phenotype of Scer\GAL4A9, ShrmA.UAS

        (Hildebrand et al., 2021)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        Rap1PIE-6

        (Mahoney et al., 2006)
        Comments
        Images (1)
        Stocks (6)
        Notes on Origin
        Discoverer

        E. M. Wallace, Sep. 1935.

        Comments
        Comments

        Used as starting point to generate deletions in 62B to 62D region.

        (Sliter et al., 1989)

        Mutation is not a simple hypermorph or hypomorph. The protein does provide some wild type activity and also antagonises the wild-type function in some manner.

        (Li et al., 1997)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        R1
        (Mahoney et al., 2006)
        Rap11
        (Hildebrand et al., 2021)
        Rap1R-1
        Rap1R
        (Li et al., 1997)
        Name Synonyms
        Secondary FlyBase IDs
          References (11)