FlyBase Allele Report: Dmel\Pp1-87B[87Bg-1]

General Information

Symbol

Dmel\Pp1-87B^87Bg-1

Species

D. melanogaster

Name

FlyBase ID

FBal0013936

Feature type

allele

Associated gene

Dmel\Pp1-87B

Associated Insertion(s)

Carried in Construct

Also Known As

ck19^e078

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Axton et al., 1990)

Mutagen

ethyl methanesulfonate

(Baksa et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: G220D.

(Dombradi and Cohen, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:12,425,030..12,425,030 [-]

Nucleotide change:

G12425030A

Amino acid change:

G220D | Pp1-87B-PA

Reported amino acid change:

G220D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Dombradi and Cohen, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Axton et al., 1990)

lethal

(Dombradi et al., 1990)

lethal | recessive

(Axton et al., 1990)

suppressor of variegation

(Baksa et al., 1993)

Phenotype Manifest In

embryonic/larval optic lobe (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

nuclear chromosome

(Axton et al., 1990)

photoreceptor cell R1 & axon (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

photoreceptor cell R2 & axon (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

photoreceptor cell R3 & axon (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

photoreceptor cell R4 & axon (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

photoreceptor cell R5 & axon (with Pp1-87B^87Bg-6)

(Babu et al., 2005)

Detailed Description

Statement

Reference

Pp1-87B^87Bg-1/Pp1-87B^87Bg-6 larvae show axon clumping at the lamina and laminal breaks with ~50% of R2-R5 axons being mistargeted to the medulla.

(Babu et al., 2005)

Strong suppressor levels of position effect vareigation and normal mitosis in neuroblasts or ganglion mother cells.

(Baksa et al., 1993)

Imaginal disc development is nearly wild-type. Mitosis in the ganglia shows a low level of abnormality (less than 4%), mostly consisting of overcondensed chromosomes without hyperploidy.

(Axton et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pp1-87B^87Bg-1 is rescued by Pp1-87B^+t5.8

(Baksa et al., 1993)

Comments

The lethality of Pp1-87B^87Bg-1 is rescued by Pp1-87B^+t5.8.

(Baksa et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

PP1α87B^87Bg-1

(Swanhart et al., 2007)

PP1α87B^e078

(Babu et al., 2005)

Pp1-87B^87Bg-1

Su-var(3)6^e078

(Dombradi and Cohen, 1992)

ck19^e078

(Axton et al., 1990, Dombradi et al., 1990)

ck19^e78

(Reuter et al., 1987)

e078

(Baksa et al., 1993)

e⁷⁸

(Gausz et al., 1981)

l(3)87Bg¹

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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