FB2024_03 , released June 25, 2024
Allele: Dmel\pll10
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General Information
Symbol
Dmel\pll10
Species
D. melanogaster
Name
FlyBase ID
FBal0013864
Feature type
allele
Associated gene
Dmel\pll
Associated Insertion(s)
Carried in Construct
Also Known As
pllrm8
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q422term.

(Towb et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,251,573..27,251,573 [-]
Nucleotide change:

C27251573T

Amino acid change:

Q422term | pll-PA; Q422term | pll-PB

Reported amino acid change:

Q422term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Towb et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemocyte density in the hemolymph of pll10/pll2 larvae is significantly lower than in the hemolymph of control larvae.

      (Qiu et al., 1998)

      Level of Drs induction of bacterially challenged pll2/pll10 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

      (Lemaitre et al., 1996)

      Injection of the pll::tort4021p construct into pll10/pll2 and pll10/Df(3R)D605 heterozygotes causes the induction of dorsoventral pattern elements, the tor::tubt4021t construct cannot induce dorsoventral pattern elements.

      (Großhans et al., 1994)

      Completely dorsalised embryos.

      (Hecht and Anderson, 1993)

      Injected dl- perivitelline fluid had no effect on embryos.

      (Stein and Nusslein-Volhard, 1992)

      Embryos derived from pll2/pll10 females are completely dorsalised. At the late cellular blastoderm stage, all the cells have rounded apical surfaces and the nuclei are located apically.

      (Leptin and Grunewald, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      pll1/pll10 is a suppressor of partially lethal - majority die | recessive phenotype of cact7

      (Qiu et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The zygotic semi-lethality of cact7 homozygotes is strongly suppressed by pll10/pll1.

      (Qiu et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong pll allele.

      (Hecht and Anderson, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (18)