FB2024_03 , released June 25, 2024
Allele: Dmel\pll1
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General Information
Symbol
Dmel\pll1
Species
D. melanogaster
Name
FlyBase ID
FBal0013855
Feature type
allele
Associated gene
Dmel\pll
Associated Insertion(s)
Carried in Construct
Also Known As
pll019
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: G220E.

(Towb et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,252,241..27,252,241 [-]
Nucleotide change:

G27252241A

Amino acid change:

G220E | pll-PA; G220E | pll-PB

Reported amino acid change:

G220E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Towb et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows brain tumours when heterozygous with the MBT chromosome. Pupal lethal when heterozygous with the MBT chromosome.

      (Riede, 2001)

      Stronger dorsalising phenotype is seen at 18oC than 29oC. Heterozygotes with pll3 produce moderately dorsalised embryos, with pll2 produce strongly dorsalised embryos.

      (Hecht and Anderson, 1993)

      Extreme pll1 embryos consist of a long, hollow tube with dorsal cuticular structures. Injection of wild-type cytoplasm into pll1 embryos partially restores the normal embryonic pattern of development.

      (Muller-Holtkamp et al., 1985)

      As in the mutant dl, lethal embryos produced by pll1 females lack ventral and lateral elements.

      (Anderson and Nusslein-Volhard, 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      pll1/pll10 is a suppressor of partially lethal - majority die | recessive phenotype of cact7

      (Qiu et al., 1998)
      Other
      Statement
      Reference

      Df(3R)mbtP, pll1 has lethal | embryonic stage phenotype

      (Riede, 2001)

      pll1, srn88 has lethal | larval stage phenotype

      (Riede, 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      spz3/pll1 does not result in neoplasms.

      (Riede, 2001)

      The zygotic semi-lethality of cact7 homozygotes is strongly suppressed by pll10/pll1.

      (Qiu et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak pll allele.

      (Hecht and Anderson, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pll019
      (Riede, 2001, Towb et al., 2001, Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)
      pll1
      Name Synonyms
      Secondary FlyBase IDs
        References (8)