FlyBase Allele Report: Dmel\ovo[M1]

General Information

Symbol

Dmel\ovo^M1

Species

D. melanogaster

Name

FlyBase ID

FBal0013435

Feature type

allele

Associated gene

Dmel\ovo

Associated Insertion(s)

Carried in Construct

Also Known As

ovo^rM1, fs(1)M1^12-5045

Key Links

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Oliver et al., 1993, Lindsley and Zimm, 1992, Oliver et al., 1990)

loss of function allele

(Garfinkel et al., 1992)

Mutagen

ethyl methanesulfonate

(Garfinkel et al., 1992, Mohler, 1977)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female

(Oliver et al., 1990)

female sterile | recessive

(Oliver and Pauli, 1998, Oliver et al., 1987, Mohler, 1977)

lethal - all die during embryonic stage | maternal effect | recessive

(Mohler, 1977)

some die during embryonic stage | recessive | maternal effect | recessive

(Mohler, 1977)

Phenotype Manifest In

egg

(Lindsley and Zimm, 1992)

egg | maternal effect

(Mohler, 1977)

egg chamber

(Oliver et al., 1990)

ventral denticle belt | larval stage

(Oliver et al., 1990)

Detailed Description

Statement

Reference

ovo^M1 allows stage 10 and later differentiation in oogenesis.

(Hinson et al., 1999)

Increased amounts of cuticular hydrocarbons.

(Wicker and Jallon, 1995)

ovo, svb phenotype.

(Garfinkel et al., 1992)

Permeable eggs.

(Lindsley and Zimm, 1992)

Most of the egg chambers of homozygous females fail to proceed past early oogenesis, and less than 30% of the wild-type number of eggs are laid per day. Larvae have few denticle belt setae. Transheterozygotes with either ovo^D2 or ovo^D3 have germ cells resembling early spermatocytes.

(Oliver et al., 1990)

Gene activity is reduced. Viable. Male germ line is fertile, female germ line has permeable eggs.

(Oliver et al., 1987)

Eggs are laid.

(Mohler and Carroll, 1984)

Homozygous females lay eggs that fail to hatch.

(Mohler, 1977)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

ovo^M1 has egg chamber phenotype, suppressible by otu^hs.PN

(Hinson et al., 1999)

ovo^M1 has egg phenotype, suppressible by otu^hs.PN

(Hinson et al., 1999)

ovo^M1 has ovary phenotype, suppressible by otu^hs.PN

(Hinson et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of otu^hs.PN to ovo^D1rv23/ovo^M1 or ovo^D1rv23/ovo^M2 mothers leads to an increase in the number of eggs produced, though in no case is hatching observed.

(Hinson et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ovo^M2

(Oliver and Pauli, 1998)

ovo^M2

(Mohler, 1977)

Fails to complement

ovo^e8F