FB2024_03 , released June 25, 2024
Allele: Dmel\Zw104
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General Information
Symbol
Dmel\Zw104
Species
D. melanogaster
Name
FlyBase ID
FBal0012293
Feature type
allele
Associated gene
Dmel\Zw10
Associated Insertion(s)
Carried in Construct
Also Known As
l(1)zw10i20, zw10i20, zw1065i20
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Williams et al., 1992)

loss of function allele

(Williams and Goldberg, 1994)
Mutagen
ethylenimine
(Williams et al., 1992, Shannon et al., 1972)
Progenitor genotype
Cytology
Description

An in-frame deletion producing a protein lacking 35 amino acids.

(Wainman et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Spermatids from mutant third instar larvae testes are multinucleated (with nuclei of variable size) and have a single large nebenkern, indicating defects in chromosome segregation and cytokinesis.

      (Wainman et al., 2012)

      Adult escaper males are sterile, testes are small and contain immotile sperm. Mutant onion stage spermatids vary considerably in size, indicative of chromosome missegregation during both meiotic divisions (nondisjunction during anaphase). Mistakes in chromosome behaviour are visualised by lagging chromosomes and chromatin bridges. Meiotic as well as mitotic defects are specific for events occurring either at anaphase onset or during anaphase proper. Mutation does not cause precocious sister chromatid separation (PSCS) during the first meiotic division but does affect cytokinesis (spermatids containing more than one nucleus per nebenkern).

      (Williams et al., 1996)

      Embryos derived from homozygous germline clones generally terminate development in the late syncytial blastoderm stages, although 15-25% of develop to later stages of embryogenesis, and 1% hatch into larvae. Mitotic synchrony is lost in embryos derived from homozygous germline clones. Chromatin bridges between nuclei, unequal segregation of chromosomes and lagging chromatids are seen at anaphase.

      (Williams and Goldberg, 1994)

      Brain cells are hyperploid. Aneuploidy involves improper chromosome segregation at anaphase: precocious sister chromatid separation. Mitotic index and the ratio of numbers of cells in anaphase relative to the total number of mitotic figures in larval brains is similar in wild type.

      (Williams et al., 1992)

      Homozygous germline clone cells are viable but yield inviable eggs.

      (Garcia-Bellido and Robbins, 1983)

      Males and homozygous females are semi-lethal. Surviving flies have reduced rough eyes, bristles on the thorax and head are sometimes missing, wings are abnormal with a thin texture and thickened veins.

      (Judd et al., 1972)

      Semilethality is polyphasic, occurs during larval, pupal and adult stages. Mosaic analysis demonstrates mutant phenotype is non-autonomous. Surviving males have rough reduced eyes, wings have thickened veins and incisions on the inner margin. Thoracic hairs are irregularly arranged, dorsocentral, scutellar, ocellar, orbital and vertical bristles are frequently absent. Sperm are immotile.

      (Shannon et al., 1972)

      temperature-sensitive

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Zw104 is rescued by Zw10+t4.6

      (Williams et al., 1992)
      Comments

      Lethal phenotype can be rescued by P element mediated transformation of a wild type mit(1)15 gene copy.

      (Williams et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Alexander.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Zw104
      l(1)zw10i20
      (Garcia-Bellido and Robbins, 1983, Judd et al., 1972, Shannon et al., 1972)
      mit(1)154
      mit(1)1565i20
      (Williams et al., 1992)
      zw1065i20
      (Wainman et al., 2012, Williams and Goldberg, 1994)
      zw10i20
      (Williams et al., 1996, Robbins, 1983)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)