FlyBase Allele Report: Dsim\Lhr[1]

General Information

Symbol

Dsim\Lhr¹

Species

D. simulans

Name

FlyBase ID

FBal0011649

Feature type

allele

Associated gene

Dsim\Lhr

Associated Insertion(s)

?{}Dsim\Lhr¹

Carried in Construct

Also Known As

Lhr¹

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Satyaki et al., 2014)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}Dsim\Lhr¹

Cytology

Description

Insertion of approximately 4kb in the predicted 5' untranslated region, resulting in reduced transcription compared to controls. The insertion appears to be moderately repetitive retrotransposed sequence.

(Brideau et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

When Drosophila simulans carries Dsim\Lhr¹, classes of hybrids between D.simulans and D.melanogaster that do not ordinarily survive are recovered. Crosses of D.melanogaster females by D.simulans males, which ordinarily produce only daughters, produce sons and daughters in a 1:1 ratio. Crosses of D.simulans females to D.melanogaster males, which ordinarily produce only sons, produce 86% sons and 14% daughters. Crosses of C(1)RM - bearing D.melanogaster females to D.simulans males, which normally produce only sons, yield a few daughters when the D.simulans males carry Dsim\Lhr¹.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Hybrid male progeny of a cross of D. melanogaster females to D. simulans Dsim\Lhr¹ males have a viability of approximately 73% relative to their hybrid female siblings.

(Maheshwari and Barbash, 2012)

Lhr^+t4.8 fully complements Dsim\Lhr¹, which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Lhr^+t4.8 to D. simulans Dsim\Lhr¹ males.

Lhr^T:Ivir\HA1 fully complements Dsim\Lhr¹, which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Lhr^T:Ivir\HA1 to D. simulans Dsim\Lhr¹ males.

(Maheshwari and Barbash, 2012)

Expression of Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^Act5C.PI in the hybrid male progeny of a cross between D.melanogaster females and D.simulans males suppresses the male hybrid rescue conferred by Dsim\Lhr¹.

Expression of Dsim\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^Act5C.PI in the hybrid male progeny of a cross between D.melanogaster females and D.simulans males suppresses the male hybrid rescue conferred by Dsim\Lhr¹.

Expression of Dvir\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^Act5C.PI in the hybrid male progeny of a cross between D.melanogaster females and D.simulans males does not significantly suppress the male hybrid rescue conferred by Dsim\Lhr¹.

Expression of Dyak\Lhr^{C.Scer\UAS.T:Avic\GFP-YFP.Venus} under the control of Scer\GAL4^Act5C.PI in the hybrid male progeny of a cross between D.melanogaster females and D.simulans males suppresses the male hybrid rescue conferred by Dsim\Lhr¹.

(Brideau and Barbash, 2011)

Complementation and Rescue Data

Rescued by

Dsim\Lhr¹ is rescued by Dsim\Lhr^Tag:HA

(Maheshwari and Barbash, 2012)

Dsim\Lhr¹ is rescued by Dsim\Lhr^{2+Cter.Tag:HA}

(Maheshwari and Barbash, 2012)

Dsim\Lhr¹ is rescued by Dsim\Lhr^+tMa

(Maheshwari and Barbash, 2012)

Dsim\Lhr¹ is rescued by Dsim\Lhr^Tag:HA

(Maheshwari and Barbash, 2012)

Partially rescued by

Dsim\Lhr¹ is partially rescued by Dsim\Lhr^2.Tag:HA

(Maheshwari and Barbash, 2012)

Dsim\Lhr¹ is partially rescued by Dsim\Lhr^{2+16aa.Tag:HA}

(Maheshwari and Barbash, 2012)

Comments

Dsim\Lhr^T:Ivir\HA1 fully complements Dsim\Lhr¹, which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Dsim\Lhr^T:Ivir\HA1 to D. simulans Dsim\Lhr¹ males.

Dsim\Lhr^2.T:Ivir\HA1 partially complements Dsim\Lhr¹, which is observed as 35-40% hybrid male viability in the progeny of a cross of D. melanogaster females carrying Dsim\Lhr^2.T:Ivir\HA1 to D. simulans Dsim\Lhr¹ males.

Dsim\Lhr^{2+Cter.T:Ivir\HA1} fully complements Dsim\Lhr¹, which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Dsim\Lhr^{2+Cter.T:Ivir\HA1} to D. simulans Dsim\Lhr¹ males.

Dsim\Lhr^{2+16aa.T:Ivir\HA1} partially complements Dsim\Lhr¹, which is observed as approximately 16% hybrid male viability in the progeny of a cross of D. melanogaster females carrying Dsim\Lhr^{2+16aa.T:Ivir\HA1} to D. simulans Dsim\Lhr¹ males.

(Maheshwari and Barbash, 2012)

Dsim\Lhr^+tMa fully complements Dsim\Lhr¹, which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Dsim\Lhr^+tMa to D. simulans Dsim\Lhr¹ males.

(Maheshwari and Barbash, 2012)

Images (0)

Mutant

Wild-type

Stocks (1)

National Drosophila Species Stock Center

14021-0251.023

Lhr¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dsim\Lhr¹

Lhr¹

(Jagannathan and Yamashita, 2021, Cooper et al., 2019, Satyaki et al., 2014, Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2012, Brideau and Barbash, 2011, Maheshwari and Barbash, 2007, Brideau et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

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