FlyBase Allele Report: Dmel\hyd[15]

General Information

Symbol

Dmel\hyd¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0010246

Feature type

allele

Associated gene

Dmel\hyd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates viral infectious disease

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis (with hyd^C017)

(Pertceva et al., 2010)

viable (with hyd^C017)

(Pertceva et al., 2010)

Phenotype Manifest In

centrosome (with hyd^C017)

(Pertceva et al., 2010)

elongation stage spermatid (with hyd^C017)

(Pertceva et al., 2010)

meiotic primary spermatocyte (with hyd^C017)

(Pertceva et al., 2010)

nucleus (with hyd^C017)

(Pertceva et al., 2010)

primary spermatocyte cyst (with hyd^C017)

(Pertceva et al., 2010)

spindle (with hyd^C017)

(Pertceva et al., 2010)

Detailed Description

Statement

Reference

hyd¹⁵/hyd^C017 mutants exhibit abnormalities in spermatogenesis. One such abnormality is for nuclei scattered through the elongated cysts to exhibit a round shape instead of a 'needle' shape. In rare cases, the group of needle-shaped nuclei can be found in the correct place in the cyst; however, some of the nuclei are evidently incorrectly condensed. Approximately 90% of nuclei and micronuclei do not reach the correct cyst pole.

hyd¹⁵/hyd^C017 mutant spermatocytes exhibit defects in cytokinesis such as the formation of two spindles in one meiotic cell. The meiotic products may have unequal amounts of chromatin or mitochondrial material. Centrosome behavior is also affected. Meiotic chromosomes are not correctly attached to the spindle in 50% of hyd¹⁵/hyd^C017 spermatids.

(Pertceva et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hyd¹⁵ has abnormal cytokinesis phenotype, enhanceable by pAbp[+]/pAbp^k10109

(Pertceva et al., 2010)

Enhancer of

Statement

Reference

hyd[+]/hyd¹⁵ is an enhancer of abnormal cytokinesis phenotype of pAbp^k10109

(Pertceva et al., 2010)

NOT Enhancer of

Statement

Reference

hyd¹⁵ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

hyd[+]/hyd¹⁵ is a non-enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

hyd¹⁵ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

hyd[+]/hyd¹⁵ is a non-suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

hyd¹⁵ is an enhancer of wing vein | ectopic phenotype of Cbl^Dv.UAS, Scer\GAL4^GMR.PF

(Robertson et al., 2000)

NOT Enhancer of

Statement

Reference

hyd¹⁵ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

hyd[+]/hyd¹⁵ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

Suppressor of

Statement

Reference

hyd¹⁵ is a suppressor of eye phenotype of EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

hyd¹⁵ is a suppressor of arista | increased number phenotype of obk¹

(Atallah et al., 2004)

NOT Suppressor of

Statement

Reference

hyd¹⁵ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

hyd[+]/hyd¹⁵ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

hyd[+]/hyd¹⁵, pAbp^k10109 has nucleus phenotype

(Pertceva et al., 2010)

hyd[+]/hyd¹⁵, pAbp^k10109 has elongation stage spermatid phenotype

(Pertceva et al., 2010)

hyd¹⁵, pAbp[+]/pAbp^k10109 has nucleus phenotype

(Pertceva et al., 2010)

hyd¹⁵, pAbp[+]/pAbp^k10109 has elongation stage spermatid phenotype

(Pertceva et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

pAbp^k10109/hyd¹⁵ trans-heterozygous double mutants exhibit spermatogenesis defects. The morphology of nuclei in the sperm head bundle are indistinguishable from the control but the nuclei are frequently scattered abnormally. Cytokinetic abnormalities are also increased in these double mutants.

(Pertceva et al., 2010)

The extent of ectopic wing vein formation found in Scer\GAL4^GMR.PF Cbl^Dv.Scer\UAS flies is enhanced in a hyd¹⁵ mutant background but does not affect the eye roughening phenotype.

(Robertson et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3718

kni^ri-1 hyd¹⁵ e¹/TM3, Sb¹

Kyoto

107197

kni^ri-1 hyd¹⁵ e¹/TM3, Sb¹

Notes on Origin

Discoverer

Matthews.

Comments

Complements: knk^ex59.

(Beitel and Krasnow, 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hyd¹⁵

(Adamson and Lajeunesse, 2012, Pertceva et al., 2010, Robertson et al., 2000)

l(3)18

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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