FlyBase Allele Report: Dmel\CycA[03946]

General Information

Symbol

Dmel\CycA⁰³⁹⁴⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0009496

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

P{PZ}CycA⁰³⁹⁴⁶

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}CycA⁰³⁹⁴⁶

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:11,833,513..11,833,513 [+]

(McClure and Schubiger, 2008, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tuberous sclerosis

modeled by Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

partially lethal - majority die

partially lethal - majority die | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CycA⁰³⁹⁴⁶ is an enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Enhancer of

Statement

Reference

CycA⁰³⁹⁴⁶ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of visible | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

NOT Suppressor of

Statement

Reference

CycA⁰³⁹⁴⁶ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

CycA⁰³⁹⁴⁶ is an enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Enhancer of

Statement

Reference

CycA⁰³⁹⁴⁶ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of leg | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of wing | ectopic | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycA[+]/CycA⁰³⁹⁴⁶ is a suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

NOT Suppressor of

Statement

Reference

CycA⁰³⁹⁴⁶ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of leg-to-wing transdetermination caused by expression of wg^Act5C.PS in clones during the mid-second larval instar is dominantly suppressed by CycA⁰³⁹⁴⁶.

(McClure and Schubiger, 2008)

Expression of both Tsc1^Scer\UAS.cTa and gig^Scer\UAS.cTa in the eye under the control of Scer\GAL4^ey.PH results in a much smaller eye than normal. Addition of one copy of CycA⁰³⁹⁴⁶ enhances the phenotype.

(Tapon et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

CycA⁰¹⁵⁵⁸

(BDGP Project Members, 1994-1999)

CycA⁰²⁴⁶¹

(BDGP Project Members, 1994-1999)

Fails to complement

CycA^rO545