FlyBase Allele Report: Dmel\l(2)gl[275]

General Information

Symbol

Dmel\l(2)gl²⁷⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0009235

Feature type

allele

Associated gene

Dmel\l(2)gl

Associated Insertion(s)

roo{}l(2)gl²⁷⁵

Carried in Construct

Also Known As

lgl^dv275, l(2)gl^DV275

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Klämbt and Schmidt, 1986)

Mutagen

spontaneous

natural population

(Mechler et al., 1985)

Progenitor genotype

Associated Insertion(s)

roo{}l(2)gl²⁷⁵

Cytology

Description

An interstitial deletion of 8kb has removed the proximal part of the l(2)gl gene.

(Opper et al., 1987)

Deletion of approximately 8kb DNA from approximately 11.5kb to 19kb (coordinates with respect to proximal end of a cloned l(2)gl region, close to the tip of 2L) which is replaced by an insertion of approximately 6.5kb DNA.

(Mechler et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

sequence_alteration

2L:13,563..22,471 [-]

Linked to:

EcoRI-BamHI restriction fragment

Comment:

Characterized by a roughly 6.5kb insertion in addition to an approximately 8kb deletion; mutation maps within an EcoRI-BamHI fragment

(Mechler et al., 1985)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

hyperplasia

(Woods et al., 1997)

lethal | recessive

(Klämbt and Schmidt, 1986)

lethal - all die before end of larval stage | recessive

(Saha and Sinha, 1996, Opper et al., 1987)

some die during larval stage | recessive

(Saha and Sinha, 1996, Opper et al., 1987)

Phenotype Manifest In

embryonic/larval brain

(Opper et al., 1987)

imaginal disc

(Saha and Sinha, 1996, Opper et al., 1987)

Detailed Description

Statement

Reference

Neoplastic overgrowth mutant. Imaginal disc tissue shows abnormal distribution of apico-lateral cell junctional markers.

(Woods et al., 1997)

Tumorous growth of the imaginal discs.

(Saha and Sinha, 1996)

Homozygous larvae die of brain and imaginal disc neoplasms.

(Opper et al., 1987)

intermediate allele: moderately enlarged brain and discs, which show enhanced growth when transplanted into wild-type females and death of host is delayed. lethal phase: larvae 79.1%, pupae 20.9%

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

l(2)gl²⁷⁵ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, crb^intra.UAS

(Tanentzapf and Tepass, 2003)

Other

Statement

Reference

Scer\GAL4^en-e16E, crb^intra.UAS, l(2)gl²⁷⁵ has lethal phenotype

(Tanentzapf and Tepass, 2003)

Phenotype Manifest In

Suppressed by

Statement

Reference

l(2)gl²⁷⁵ has phenotype, suppressible by Dpse\l(2)gl^+t12.2

(Torok et al., 1993)

Enhancer of

Statement

Reference

l(2)gl²⁷⁵ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, crb^intra.UAS

(Tanentzapf and Tepass, 2003)

Suppressor of

Statement

Reference

l(2)gl[+]/l(2)gl²⁷⁵ is a suppressor | partially of embryonic/first instar larval cuticle phenotype of sdt^EH681

(Tanentzapf and Tepass, 2003)

l(2)gl²⁷⁵/l(2)gl²⁷⁵ is a suppressor | partially of embryonic/first instar larval cuticle phenotype of sdt^EH681

(Tanentzapf and Tepass, 2003)

l(2)gl[+]/l(2)gl²⁷⁵ is a suppressor of embryonic/first instar larval cuticle phenotype of crb^11A22

(Tanentzapf and Tepass, 2003)

l(2)gl²⁷⁵/l(2)gl²⁷⁵ is a suppressor of embryonic/first instar larval cuticle phenotype of crb^11A22

(Tanentzapf and Tepass, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Mutant phenotype incompletely rescued by Dpse\l(2)gl^+t12.2, but rescue is incomplete due to a second-site semi-lethal factor on chromosome 2.

(Torok et al., 1993)

Complementation and Rescue Data

Fails to complement

Rescued by

l(2)gl²⁷⁵ is rescued by l(2)gl^+t13.1

(Saha and Sinha, 1996)

l(2)gl²⁷⁵ is rescued by l(2)gl^+t13.1

(Opper et al., 1987)

Comments

Brain and imaginal disc neoplasm phenotype can be completely rescued by l(2)gl^+t13.1.

(Opper et al., 1987)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Isolated from: Sinii Gay, Far East, USSR population.

(Mechler et al., 1985)

Comments

Homozygous embryos show no l(2)gl expression in the brain.

(Klämbt and Schmidt, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

275

(Gateff, 1978)

l(2)gl²⁷⁵

(Zarnescu et al., 2005)

l(2)gl^DV275

(Torok et al., 1993, Gateff and Mechler, 1989, Klämbt and Schmidt, 1986, Mechler et al., 1985)

l(2)glDV275

(Trunova and Shearn, 2005, Opper et al., 1987)

lgl^DV275

(Trunova and Shearn, 2004, Saha and Sinha, 1996)

lgl^dv275

(Tanentzapf and Tepass, 2003, Woods et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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