FlyBase Allele Report: Dmel\Su(var)2-10[03697]

(Pardi et al., 2011, Mohr and Boswell, 2002, Hari et al., 2001, Mohr and Boswell, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Hari et al., 2001, Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Mohr and Boswell, 1999)

some die during embryonic stage | recessive

(Mohr and Boswell, 1999)

Phenotype Manifest In

eye | somatic clone

(Betz et al., 2001)

lens | somatic clone

(Betz et al., 2001)

ommatidium | somatic clone

(Betz et al., 2001)

photoreceptor neuron | somatic clone

(Betz et al., 2001)

Detailed Description

Statement

Reference

When homozygous mutant clones are made in the eye, the lens structure completely fails to develop and is replaced by a heterogeneous bulged-out surface, lacking bristles. Partially differentiated lenses surround the border of the clone. Cellular differentiation into photoreceptors and other cell types fails, especially inn the centre of the clones. Along the clonal borders partially differentiated ommatidia can be seen, with incomplete sets of photoreceptors. Other clones apparently undergo necrotic and/or apoptotic cell death, because scars in the eyes are frequently found.

(Betz et al., 2001)

Cuticles of homozygous embryos are indistinguishable from wild-type (97%) or occasionally have minor defects (3%).

(Mohr and Boswell, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(var)2-10⁰³⁶⁹⁷ is an enhancer of neoplasia phenotype of hop^Tum

(Betz et al., 2001)

NOT Enhancer of

Statement

Reference

Su(var)2-10⁰³⁶⁹⁷ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

Su(var)2-10⁰³⁶⁹⁷ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Su(var)2-10⁰³⁶⁹⁷/Su(var)2-10[+] is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

Su(var)2-10⁰³⁶⁹⁷ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

Su(var)2-10⁰³⁶⁹⁷/Su(var)2-10[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, p53^UAS.Ex

(Pardi et al., 2011)

Su(var)2-10⁰³⁶⁹⁷ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

A loss of heterozygosity assay, using mwh¹ as a marker, reveals that a Su(var)2-10⁰³⁶⁹⁷ heterozygous background increases the number of mwh¹ clones after irradiation with 250 rad of X-rays, in p53^5A-1-4 mutants.

The rough eye phenotype found at 29[o]C in flies expressing p53^Scer\UAS.Ex under the control of Scer\GAL4^GMR.PF is not affected by a Su(var)2-10⁰³⁶⁹⁷ heterozygous background.

(Pardi et al., 2011)

The addition of Su(var)2-10⁰³⁶⁹⁷ to Df(1)os¹ mutants leads to a slight suppression of the small eye phenotype seen in Df(1)os¹ flies. The further addition of Stat92E⁰⁶³⁴⁶ increases the suppression.

(Betz et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Su(var)2-10¹

(Hari et al., 2001)

Su(var)2-10²

(Hari et al., 2001)

Su(var)2-10^1bb

(Mohr and Boswell, 1999)