FB2024_03 , released June 25, 2024
Allele: Dmel\ken02970
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General Information
Symbol
Dmel\ken02970
Species
D. melanogaster
Name
FlyBase ID
FBal0008011
Feature type
allele
Associated gene
Dmel\ken
Associated Insertion(s)
P{PZ}ken02970
Carried in Construct
Also Known As
l(2)02970
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Arbouzova, 2006)
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}ken02970
Cytology
Description

Insertion between the translation start site and the transcription start site.

(Lukacsovich et al., 2003)

P{PZ} insertion in the ken gene (at position 15,843-15,850, coordinates according to EMBL accession record AB010261).

(Lukacsovich et al., 1999)

P{PZ} insertion in the 5' region of the transcription unit.

(Kuhnlein et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ken02970/Df(2R)Chig230 transheterozygous individuals exhibit antennal abnormalities and variable loss of genital structures and are recovered at 0.6% of the expected frequency.

      (Arbouzova, 2006)

      ken1/ken02970 escapers have abnormal terminalia (phenotype is 100% penetrant).

      (Lukacsovich et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ken[+]/ken02970 is a suppressor of visible | somatic clone phenotype of wgAct5C.PS

      (McClure and Schubiger, 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ken[+]/ken02970 is a suppressor of leg | somatic clone phenotype of wgAct5C.PS

      (McClure and Schubiger, 2008)

      ken[+]/ken02970 is a suppressor of wing | ectopic | somatic clone phenotype of wgAct5C.PS

      (McClure and Schubiger, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The frequency of leg-to-wing transdetermination caused by expression of wgAct5C.PS in clones during the mid-second larval instar is dominantly suppressed by ken02970.

      (McClure and Schubiger, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      kenk11035

      (BDGP Project Members, 1994-1999)
      Fails to complement

      ken1

      (Kuhnlein et al., 1998)

      ken08253

      (Kuhnlein et al., 1998)

      ken00628

      (BDGP Project Members, 1994-1999)

      kenk08507b

      (BDGP Project Members, 1994-1999)

      ken1

      (BDGP Project Members, 1994-1999)

      ken08253

      (BDGP Project Members, 1994-1999)
      Comments

      The P{PZ}ken00628 insertion is in the intergenic region between the divergently transcribed ken and Thiolase genes. P{PZ}ken00628 fails to complement P{PZ}ken02970 (an insertion in the ken coding region) and P{lacW}Thiolasek09828, but P{PZ}ken02970 and P{lacW}Thiolasek09828 complement each other. This indicates that the P{PZ}ken00628 insertion is affecting both the ken and Thiolase genes and that the P{lacW}Thiolasek09828 insertion is a mutation in the Thiolase gene.

      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Separable from: a second site mutation that is responsible for the lethality.

      (Arbouzova, 2006)
      Comments
      Comments

      Excision of the P{PZ} element results in fully viable flies.

      (Kuhnlein et al., 1998)

      The strength of the following ken alleles can be classified from the weakest to the strongest as follows: ken1 <= ken02970 < kenk11035 < Df(2R)Chig230.

      (Arbouzova, 2006)

      Complements: l(2)k01015k01015. Complements: l(2)k06003k06003. Complements: Ca-P60Ak08308ab. Complements: Ca-P60Ak09025. Complements: Thiolasek09828. Complements: ytrk13108. Complements: eIF6k13214.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      References (14)