Females with germline clones lay eggs with fused dorsal appendages and the embryos have an expanded nervous system. Only a few eggs are laid because early oogenesis is blocked due to the development of egg chambers containing multiple oocyte-nurse cell complexes. Germ cell divisions in the egg chambers are not regulated. Follicle cells frequently lose their cuboidal or columnar shape and exit the epithelium around the oocyte and its adjacent nurse cells. Follicle cells at the posterior of egg chamber become mesenchymal-like indicating they have not adopted a border cell fate. Stalk cells are determined correctly but are usually disorganised compared to wild type. Homozygous embryos exhibit expansion of the nervous system where the epidermal layer is missing, gut is undifferentiated.
Homozygous egh27 germline has abnormal egg chambers with fused filaments.
Lefevre.
Maternal germline clonal analysis demonstrates a maternal effect, neurogenic defects.