Females with germline clones lay eggs with fused dorsal appendages and the embryos have an expanded nervous system. Only a few eggs are laid because early oogenesis is blocked due to the development of egg chambers containing multiple oocyte-nurse cell complexes. Germ cell divisions in the egg chambers are not regulated and the relative frequency of cell division in the egg chambers is approximately 80% greater around the oocyte compared to wild type (they frequently lose their cuboidal or columnar shape and exit the epithelium around the oocyte and its adjacent nurse cells as they divide perpendicular to the plane of the follicular epithelium). Follicle cells line the wall of the germarium but fail to extend processes leading to failure to organise cysts. Follicle cells at the posterior of egg chamber become mesenchymal-like indicating they have not adopted a border cell fate. Stalk cells are determined correctly but are usually disorganised compared to wild type. Homozygous embryos exhibit loss of ventral and cephalic structures and exhibit an intermediate neurogenic phenotype.
Lethality is rescued by egh+t7, rescued adults are fertile.
Lefevre.