FB2024_03 , released June 25, 2024
Allele: Dmel\hop14
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General Information
Symbol
Dmel\hop14
Species
D. melanogaster
Name
FlyBase ID
FBal0005525
Feature type
allele
Associated gene
Dmel\hop
Associated Insertion(s)
Carried in Construct
Also Known As
hopVA275
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Perrimon and Mahowald, 1986)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: S1062F. The mutation is within the kinase domain.

(Luo et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,362,230..11,362,230 [-]
Nucleotide change:

C11362230T

Amino acid change:

S1062F | hop-PA

Reported amino acid change:

S1062F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Luo et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The concentration of circulating hemocytes in mutant larvae and the distribution of the different blood cell types is not different from that of controls.

      (Remillieux-Leschelle et al., 2002)

      100% viable in transheterozygous combination with hop25.

      (Harrison et al., 1998)

      Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

      (Perrimon and Mahowald, 1986)

      larval/pupal lethal hop14/hop25 40% viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      hop14, upd1YM55 has partially lethal | recessive phenotype

      (Harrison et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Viability of hop14/hop25 flies is reduced if the flies also carry osupd-4.

      (Harrison et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lefevre.

      Comments
      Comments

      Complement hop25 to 40%.

      (Perrimon and Mahowald, 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      VA275
      (Luo et al., 1999)
      hop14
      hopVA275
      (Remillieux-Leschelle et al., 2002, Harrison et al., 1998)
      l(1)VA275
      l(1)hopVA275
      (Perrimon and Mahowald, 1986)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0005933
      References (4)