FB2024_03 , released June 25, 2024
Allele: Dmel\emc20
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General Information
Symbol
Dmel\emc20
Species
D. melanogaster
Name
FlyBase ID
FBal0003695
Feature type
allele
Associated gene
Dmel\emc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chen et al., 1996, Cabrera et al., 1994, van Doren et al., 1992)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A small fraction of homozygous embryos fail to hatch. These embryos show some defects in head involution and head skeleton formation.

      (Chen et al., 1996)

      Ectopic macrochaetes at many positions on each heminotum. Expression in the wing imaginal discs of an ac-lacZ reporter construct corresponds to the positions at which ectopic bristles would be expected to arise.

      (van Doren et al., 1992)

      homozygous viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      emc20, pydJ4 has lethal | recessive phenotype

      (Chen et al., 1996)

      emc20, pydJ14 has lethal | recessive phenotype

      (Chen et al., 1996)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      emc20 is an enhancer of sense organ phenotype of pydJ14

      (Chen et al., 1996)

      emc20 is an enhancer of cephalopharyngeal skeleton phenotype of pydJ14

      (Chen et al., 1996)

      emc20 is an enhancer of ventral denticle belt phenotype of pydJ14

      (Chen et al., 1996)

      emc20 is an enhancer of embryonic/first instar larval cuticle | dorsal phenotype of pydJ14

      (Chen et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of emc20 strongly enhances the pydJ14 phenotype, resulting in extra sensory organs in positions characteristic of pyd mutants rather than emc mutants. emc20 pydJ14 or emc20 pydJ4 double homozygotes die as embryos or early larvae. emc20 pydJ14 embryos usually have severe defects in head involution and lack the cephalo-pharyngeal skeleton. Some embryos also have holes in the dorsal cuticle of the head. The denticle belts are sparse and disorganised.

      (Chen et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Spann.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      emc20
      emcM7
      (Cabrera et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)