FB2024_03 , released June 25, 2024
Allele: Dmel\egMz360
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General Information
Symbol
Dmel\egMz360
Species
D. melanogaster
Name
FlyBase ID
FBal0003524
Feature type
allele
Associated gene
Dmel\eg
Associated Insertion(s)
P{GawB}egMz360
Carried in Construct
Also Known As
eg-Gal4, eagle-GAL4, MZ360, eagleGal4, egGAL4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
P-element activity
(Lundell and Hirsh, 1998, Dittrich et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{GawB}egMz360
Cytology
Description

Insertion of a P{GawB} element approximately 200bp upstream of 5' exon A2.

(Dittrich et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the ventral nerve cords of stage 16 egMz360 mutant embryos, there is a loss of ability to take up serotonin in approximately 1/4 of hemisegments.

      (Couch et al., 2004)

      Homozygotes have a held out wing phenotype.

      (Gritzan et al., 2002)

      Mutants exhibit an almost wild type pattern of serotonin neurons in the abdominal region but only single cells in the thoracic segments. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron.

      (Lundell and Hirsh, 1998)

      Homozygotes have a 'wings held out' phenotype.

      (Dittrich et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      egMz360 has serotonin neuron & ventral nerve cord phenotype, non-enhanceable by robo2X123/robo2X123

      (Couch et al., 2004)
      Suppressed by
      Statement
      Reference

      egMz360 has serotonin neuron & ventral nerve cord phenotype, suppressible by robo2EP2582/robo2EP2582

      (Couch et al., 2004)
      NOT Enhancer of
      Statement
      Reference

      egMz360/egMz360 is a non-enhancer of serotonin neuron & ventral nerve cord phenotype of robo2X123

      (Couch et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In the ventral nerve cords from stage 16 egMz360/egMz360 embryos, the number of hemisegments showing loss of ability to take up serotonin is not significantly increased by leaX123/leaX123. Loss of serotonin uptake activity in the ventral nerve cords of stage 16 egMz360/egMz360 embryos is suppressed by the presence of leaEP2582/leaEP2582.

      (Couch et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      eg18B

      (Dittrich et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      egMZ360
      (Gritzan et al., 2002)
      egMz360
      (Herrero et al., 2014)
      egmz360
      (Lee and Lundell, 2007, Sykes and Condron, 2005, Lundell and Hirsh, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)