FlyBase Allele Report: Dmel\dx[S1M]

General Information

Symbol

Dmel\dx^S1M

Species

D. melanogaster

Name

FlyBase ID

FBal0003263

Feature type

allele

Associated gene

Dmel\dx

Associated Insertion(s)

Carried in Construct

Also Known As

dx^sm

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Xu and Artavanis-Tsakonas, 1990)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | recessive

(Xu and Artavanis-Tsakonas, 1990)

visible

(Fostier et al., 1998)

visible | recessive

(Mukherjee et al., 2005, Xu and Artavanis-Tsakonas, 1990)

Phenotype Manifest In

eye

(Busseau et al., 1994)

ocellus

(Busseau et al., 1994)

wing

(Fostier et al., 1998, Busseau et al., 1994)

wing margin

(Mukherjee et al., 2005)

wing vein

(Mukherjee et al., 2005, Fostier et al., 1998)

Detailed Description

Statement

Reference

dx^S1M/Y adults have mild distal notching of the wing and mild distal thickening (deltas) in the wing veins.

(Mukherjee et al., 2005)

Thickened wing veins and wing margin loss.

(Fostier et al., 1998)

Viable. Extra wing vein material at distal ends, nicked margins an tips. Ocelli are fused or closed, hairs and bristles are abnoral or missing. Weak rough eye phenotype: irregular ommatidia, bristles are duplicated or missing. No visual abnormality. Hemizygote males with N^Ax-E2 are sterile.

(Xu and Artavanis-Tsakonas, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dx^S1M has visible | recessive phenotype, enhanceable by krz^S047819/krz[+]

(Mukherjee et al., 2005)

dx^S1M has visible | recessive phenotype, enhanceable by krz[+]/krz^S095214

(Mukherjee et al., 2005)

dx^S1M has lethal phenotype, enhanceable by M285^M285

(Go and Artavanis-Tsakonas, 1998)

Other

Statement

Reference

N^nd-1, Su(dx)^sp/Su(dx)[+], dx^S1M has lethal phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has visible phenotype

(Cornell et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

dx^S1M has wing margin phenotype, enhanceable by krz^S047819/krz[+]

(Mukherjee et al., 2005)

dx^S1M has wing vein phenotype, enhanceable by krz^S047819/krz[+]

(Mukherjee et al., 2005)

dx^S1M has wing margin phenotype, enhanceable by krz[+]/krz^S095214

(Mukherjee et al., 2005)

dx^S1M has wing vein phenotype, enhanceable by krz[+]/krz^S095214

(Mukherjee et al., 2005)

Suppressed by

Statement

Reference

dx^S1M has wing vein phenotype, suppressible by Su(dx)⁵⁶

(Fostier et al., 1998)

dx^S1M has wing phenotype, suppressible by Su(dx)⁵⁶

(Fostier et al., 1998)

dx^S1M has wing vein phenotype, suppressible by Df(2L)Su(dx)-7

(Fostier et al., 1998)

dx^S1M has wing phenotype, suppressible by Df(2L)Su(dx)-7

(Fostier et al., 1998)

dx^S1M has wing vein phenotype, suppressible by Su(dx)^sp

(Fostier et al., 1998)

dx^S1M has wing phenotype, suppressible by Su(dx)^sp

(Fostier et al., 1998)

dx^S1M has wing vein phenotype, suppressible by Su(dx)⁴

(Fostier et al., 1998)

dx^S1M has wing phenotype, suppressible by Su(dx)⁴

(Fostier et al., 1998)

dx^S1M has wing phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx^S1M has eye phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx^S1M has ocellus phenotype, suppressible by Su(dx)[+]/Su(dx)¹

(Busseau et al., 1994)

dx^S1M has wing phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

dx^S1M has eye phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

dx^S1M has ocellus phenotype, suppressible by Su(dx)^sp/Su(dx)[+]

(Busseau et al., 1994)

Enhancer of

Statement

Reference

dx^S1M is an enhancer of phenotype of N^nd-3

(Hing et al., 1994)

Other

Statement

Reference

da², dx^S1M/dx[+] has follicle cell phenotype

(Smith et al., 2002)

da², dx^S1M has follicle cell phenotype

(Smith et al., 2002)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has wing vein phenotype

(Cornell et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The notching and vein thickening phenotypes seen in dx^S1M hemizygous males are enhanced by krz^S047819/+ or krz^S095214/+.

(Mukherjee et al., 2005)

The mutant wing, eye and ocelli phenotypes are dominantly suppressed by Su(dx)¹, Su(dx)² and Su(dx)^sp.

(Busseau et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Schalet.

Comments

Strong dx allele.

(Xu and Artavanis-Tsakonas, 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dx^S1M

dx^SM

(Mukherjee et al., 2005, Go and Artavanis-Tsakonas, 1998, Busseau et al., 1994, Xu and Artavanis-Tsakonas, 1990)

dx^sm

(Cornell et al., 1999, Fostier et al., 1998, Hing et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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