FB2024_03 , released June 25, 2024
Allele: Dmel\dwg8
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General Information
Symbol
Dmel\dwg8
Species
D. melanogaster
Name
FlyBase ID
FBal0003230
Feature type
allele
Associated gene
Dmel\dwg
Associated Insertion(s)
Carried in Construct
Also Known As
zw-562j1, l(1)zw5j1
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
Progenitor genotype
Cytology
Description

Amino acid replacement: R14G.

(Gaszner et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,727,874..2,727,874 [+]
Nucleotide change:

C2727874G

Amino acid change:

R15G | dwg-PA

Reported amino acid change:

R14G

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Gaszner et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Growth rate of first instar larvae is variable. Mosaic analysis demonstrates mutant phenotype is autonomous. Individuals survive when Dp(1;4)wm65g, Dp(1;3)wm49a or Dp(1;3)N264-58 is present. Surviving males have rough, reduced darkened eyes, vibrissae are sparse and orbital, ocellar and vertical bristles often absent. Wing veins are thick and the inner wing margin has incisions. Males are fertile.

      (Shannon et al., 1972)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      dwg8 is an enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PF

      (Blanton et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      dwg8 is rescued by dwgHsp83.PG

      (Gaszner et al., 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Judd, 1 Oct. 1962.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      62j1
      (Thierry-Mieg, 1982)
      dwg8
      (Tang et al., 2023, Haelterman et al., 2014)
      l(1)zw5j1
      (Judd et al., 1972, Shannon et al., 1972)
      zw-562j1
      (Blanton et al., 2003, Liu and Lim, 1975)
      zw562j1
      (Gaszner et al., 1999)
      zw5j1
      (Robbins, 1983)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)