FlyBase Allele Report: Dmel\dpp[s22]

General Information

Symbol

Dmel\dpp^s22

Species

D. melanogaster

Name

FlyBase ID

FBal0003091

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

S22, shv^S22

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Segal and Gelbart, 1985)

Progenitor genotype

Caused by aberration

In(2L)dpp^s22

Cytology

Description

Breakpoint allele.

(St. Johnston et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with dpp^TgR46.1)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s3)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s5)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s7)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s12)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s13)

(Stultz et al., 2005)

lethal | larval stage (with dpp^s20)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s3)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s5)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s7)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s12)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s13)

(Stultz et al., 2005)

lethal | pharate adult stage (with dpp^s20)

(Stultz et al., 2005)

lethal | recessive

(St. Johnston et al., 1990, Segal and Gelbart, 1985)

lethal - all die before end of P-stage (with dpp^s11)

(Stultz et al., 2005)

some die during pharate adult stage (with dpp^s11)

(Stultz et al., 2005)

viable (with dpp^s6)

(Stultz et al., 2005)

viable (with dpp^s-hc1)

(Stultz et al., 2005)

visible (with dpp^s6)

(Stultz et al., 2005)

visible (with dpp^s11)

(Stultz et al., 2005)

visible (with dpp^s-hc1)

(Stultz et al., 2005)

visible | dominant

(Segal and Gelbart, 1985)

Phenotype Manifest In

adult head capsule (with dpp^s11)

(Stultz et al., 2005)

adult head capsule (with dpp^s-hc1)

(Stultz et al., 2005)

embryonic/larval midgut

(Masucci and Hoffmann, 1993)

gastric caecum

(Masucci and Hoffmann, 1993)

gastric caecum primordium

(Hursh et al., 1993)

maxillary palp

(St. Johnston et al., 1990)

vibrissal bristle

(St. Johnston et al., 1990)

wing (with dpp^s11)

(Stultz et al., 2005)

wing vein

(St. Johnston et al., 1990)

wing vein L2

(de Celis, 1997)

wing vein L2 (with dpp^s4)

(Sotillos and de Celis, 2006)

wing vein L3

(de Celis, 1997)

wing vein L4

(de Celis, 1997)

wing vein L4 (with dpp^s4)

(Sotillos and de Celis, 2006)

wing vein L5

(de Celis, 1997)

wing vein L5 (with dpp^s4)

(Sotillos and de Celis, 2006)

Detailed Description

Statement

Reference

The wings of dpp^s4/dpp^s22 flies have dramatically shortened L2, L4 and L5 wing veins (only proximal regions of these veins remain) and lack both cross veins.

(Sotillos and de Celis, 2006)

Adult escapers of dpp^s22 in combination with either dpp^s20, dpp^s7, dpp^s3, dpp^s12, dpp^s5 or dpp^s13 have wing and head capsule defects.

50% of dpp^s22/dpp^s11 animals develop as adults with head capsule and wing defects, while the remaining 50% die as pharate adults.

(Stultz et al., 2005)

Homozygous dorsoventral clones (induced before the segregation of the dorsal and ventral compartments) remove the distal regions of LII, cause gaps in LIII in anterior clones, and remove most of LIV and LV in posterior clones. Clones restricted to one wing surface (dorsal or ventral) have minimal effects on vein differentiation. dpp^s4/dpp^s8 flies lack most of wing veins LII, LIV and LV.

(de Celis, 1997)

Gastric caeca are absent.

(Hursh et al., 1993)

Midguts from dpp^s11/dpp^s22 mutant larvae exhibit variable gastric caeca length and/or absence defects. Those animals which lack gastric caecae die as larvae or pupae. Adults which do eclose do so with a 5 day delay.

(Masucci and Hoffmann, 1993)

Weak pharate adult lethal when heterozygous with other dpp alleles. Adult escapers display wing venation defects, reduced maxillary palps and vibrissae head capsule.

(St. Johnston et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

The wings of dpp^Scer\UAS.cSa; Scer\GAL4^dpp.3KK flies are covered in ectopic vein tissue. This phenotype is rescued by dpp^s22/dpp^s4. The resulting flies have a milder shortvein phenotype than dpp^s22/dpp^s4 flies.

(Sotillos and de Celis, 2006)

Belongs to the shv-p class of alleles.

(St. Johnston et al., 1990)

Allele class: shv-p

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25139

In(2L)dpp^s22, dpp^s22 stc⁶/CyO

Notes on Origin

Discoverer

Comments

Used to examine regulation of dpp-Ecol\lacZ promoter fusions, whose expression depends on endogenous dpp function demonstrating that positive autoregulation maintains dpp expression in the visceral mesoderm.

(Hursh et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

S22

(Brugger et al., 2004)

dpp^s22

(Sotillos and de Celis, 2006)

s22

(Stultz et al., 2005)

shv^S22

(Segal and Gelbart, 1985)

shv^s22

(Sotillos and de Celis, 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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