FB2024_03 , released June 25, 2024
Allele: Dmel\cu1
Open Close
General Information
Symbol
Dmel\cu1
Species
D. melanogaster
Name
FlyBase ID
FBal0002131
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Splice acceptor site mutation at cu-RE exon 5, which results in an alternative splice site usage. This leads to an 11bp deletion followed by both a frameshift in the open reading frame and a premature translational stop signal.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

CAG11207357TCG

Comment:

A two base mutation in the intron includes the first base of the splice acceptor site. This leads to use of a cryptic downstream splice acceptor site. This is turn leads to an 11bp deletion, a frameshift and early translation termination.

Inserted_sequence:

TC

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Good nutrition of larvae enhances curled character as does high temperature in last day of pupal life.

Wings curved upward throughout length and slightly divergent. Body color dark. Postscutellars erect and crossed. RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (653)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0049404
References (9)