FlyBase Allele Report: Dmel\csw[1]

General Information

Symbol

Dmel\csw¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001920

Feature type

allele

Associated gene

Dmel\csw

Associated Insertion(s)

Carried in Construct

Also Known As

csw^C114

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Allard et al., 1996, Perkins et al., 1992)

Mutagen

X ray

(Perkins et al., 1996, Perkins et al., 1992)

Progenitor genotype

Cytology

euchromatic aberration

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo | germline clone | maternal effect

(Perkins et al., 1996, Perrimon et al., 1989)

embryonic head | germline clone | maternal effect

(Perkins et al., 1996)

eye disc

(Smith et al., 2002)

photoreceptor | larval stage

(Botham et al., 2008)

Detailed Description

Statement

Reference

In the larval eye discs of csw¹ mutants only a few photoreceptors develop along the morphogenetic furrow. The residual photoreceptors are mostly R8 cells.

(Botham et al., 2008)

csw¹/Y third larval instar eye discs show an increase in the number of apoptotic cells compared to wild type. There is also a zone of apoptotic cells anterior to the morphogenetic furrow, which is not seen in wild-type discs.

(Smith et al., 2002)

Has no "Enhancer of sev" activity. Clones of mutant cells induced during the first larval instar only rarely develop photoreceptors.

(Allard et al., 1996)

csw¹ germline clone mosaics cause maternal effect lethality. There is slight paternal rescue of the germline clone phenotype; 74% embryos progress further through embryogenesis, complete germband shortening, often complete head involution and exhibit the corkscrew shape. Embryos that do not receive a wild type copy from their father (26%) die in the shape of a 'U' when the germband is fully extended or as it is shortening, often do not complete head involution.

(Perkins et al., 1996)

Abnormal development of terminal internal structures. Syncytial and cellular blastoderm embryos show reduced posterior tll domain. hb remains as a posterior cap and the seventh ftz stripe expands posteriorly, both due to lack of hkb repressing activity.

(Perkins et al., 1992)

Lethality occurs during larval and pupal stages. Phenotype of homozygous germ line clones is maternal effect lethal.

(Perrimon et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

csw¹ has photoreceptor | larval stage phenotype, non-suppressible by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^GMR.PF

(Botham et al., 2008)

csw¹ has photoreceptor | larval stage phenotype, non-suppressible by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^hs.PB

(Botham et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Zzzz\cagA^{Scer\UAS.T:Ivir\HA1} under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^hs.PB does not significantly increase the number of photoreceptors seen in csw¹ mutant larval eye discs.

(Botham et al., 2008)

Complementation and Rescue Data

Partially rescued by

csw¹ is partially rescued by csw^UAS.Tag:FLAG/Scer\GAL4^GMR.PF

(Botham et al., 2008)

csw¹ is partially rescued by csw^UAS.Tag:FLAG/Scer\GAL4^hs.PB

(Botham et al., 2008)

Comments

Expression of csw^{Scer\UAS.T:Zzzz\FLAG} under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^hs.PB significantly increases the number of photoreceptors seen in csw¹ mutant larval eye discs.

(Botham et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lefevre.

Comments

Maternal germline clonal analysis demonstrates there is a maternal effect lethal phenotype, twisted embryos.

(Perrimon et al., 1989)

Phenotypic series of csw mutant embryos derived from homozygous germline clones, classified according to cuticular phenotype: csw⁵ = csw^LE120 > csw¹ = csw^13-87 > csw^e13d.3 > csw⁷ = csw⁶.

(Perkins et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

C114

(Perrimon et al., 1985)

csw¹

csw^C114

(Botham et al., 2008, Smith et al., 2002, Allard et al., 1998, Allard et al., 1996, Perkins et al., 1996, Perkins et al., 1992, Perrimon et al., 1989)

l(1)C114

Name Synonyms

Secondary FlyBase IDs

References (8)

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