FlyBase Allele Report: Dmel\Dll[5]

General Information

Symbol

Dmel\Dll⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0001002

Feature type

allele

Associated gene

Dmel\Dll

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sunkel and Whittle, 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Sunkel and Whittle, 1987)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Sunkel and Whittle, 1987)

some die during embryonic stage | recessive

(Sunkel and Whittle, 1987)

visible | dominant

(Sunkel and Whittle, 1987)

Phenotype Manifest In

antenna

(Sunkel and Whittle, 1987)

antennal sense organ

(Sunkel and Whittle, 1987)

embryonic/larval labial organ

(Sunkel and Whittle, 1987)

hypostomal sclerite

(Sunkel and Whittle, 1987)

Keilin organ

(Sunkel and Whittle, 1987)

terminal organ

(Sunkel and Whittle, 1987)

Detailed Description

Statement

Reference

Embryos have normal mouth hooks and ventral organs, but missing an average of 5 cirri from the anterior row and 7 cirri from the posterior row. Also the ventral organ often includes extra papillae of unknown origin. Dll mutations do not revert the homeotic transformations induced by ectopic Dfd expression.

(O'Hara et al., 1993)

Heterozygotes show a transformation of distal segments of the antenna to the corresponding segments of the mesothoracic leg. Homozygous and hemizygous embryos lack the H piece, labial sense organ, antennal sense organ, maxillary sense organ and Keilin's organs.

(Sunkel and Whittle, 1987)

Dll⁵/+ like Dll¹/+. Dll⁵/Dll⁵ and Dll⁵/Dll¹ are late embryonic lethals; show loss of antennae, maxillary and labial sense organs, as well as the 'H' piece and Keilin's organs from all three thoracic segments. Occasional abnormalities in setal bands of segments posterior to prothorax; setal bands or spinules may be deleted or adjacent bands fused. Posterior end of larva normal.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dll⁵/Dll[+] is an enhancer of increased cell death phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Other

Statement

Reference

BEAF-32^UAS.cYa, Dll⁵, Scer\GAL4^GMR.PS has visible phenotype

(Yamaguchi et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dll⁵/Dll[+] is an enhancer of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

NOT Enhancer of

Statement

Reference

Dll⁵/Dll[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Suppressor of

Statement

Reference

Dll⁵/Dll[+] is a suppressor of wing margin phenotype of Scer\GAL4^NP7148, ss^UAS.A5

(Adachi-Yamada et al., 2005)

NOT Suppressor of

Statement

Reference

Dll⁵/Dll[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Other

Statement

Reference

BEAF-32^UAS.cYa, Dll⁵, Scer\GAL4^GMR.PS has eye phenotype

(Yamaguchi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Genetic crossing of the Dref^Scer\UAS.cSa expressing strain with Dll⁵ results in a severe small eye phenotype.

(Hirose et al., 2001)

Flies expressing BEAF-32^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PS in a Dll⁵ background have a severe small eye phenotype.

(Yamaguchi et al., 2001)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

106970

Dll⁵/SM5

Notes on Origin

Discoverer

Tiong, 1983.

Tiong.

(Sunkel and Whittle, 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ba⁵

(Lindsley and Zimm, 1992)

Dll⁵

(Merzetti et al., 2013, Kuzin et al., 2011, Christensen et al., 2009.7.22, Dey et al., 2009, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Yoshioka et al., 2007, Hirose et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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