FlyBase Allele Report: Dmel\ash1[21]

General Information

Symbol

Dmel\ash1²¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000753

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tripoulas et al., 1996)

Mutagen

ethyl methanesulfonate

(Tripoulas et al., 1996, Tripoulas et al., 1994)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G4863A. Amino acid replacement: E1284K.

(Tripoulas et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult abdominal segment 4 (with ash1²²)

(Dorafshan et al., 2019)

adult abdominal segment 5 (with ash1²²)

(Dorafshan et al., 2019, Dorafshan et al., 2019)

adult abdominal segment 6 (with ash1²²)

(Dorafshan et al., 2019, Dorafshan et al., 2019)

adult mesothoracic segment (with ash1²²)

(Dorafshan et al., 2019)

adult mesothoracic segment | ectopic (with ash1²²)

(Dorafshan et al., 2019)

haltere (with ash1²²)

(Dorafshan et al., 2019, Dorafshan et al., 2019)

mesothoracic leg (with ash1²²)

(Dorafshan et al., 2019)

mesothoracic leg | ectopic (with ash1²²)

(Dorafshan et al., 2019)

mesothoracic tibial apical bristle (with ash1²²)

(Dorafshan et al., 2019)

metathoracic bristle | ectopic (with ash1²²)

(Dorafshan et al., 2019)

metathoracic leg (with ash1²²)

(Dorafshan et al., 2019)

metathoracic leg | ectopic (with ash1²²)

(Dorafshan et al., 2019)

wing | ectopic (with ash1²²)

(Dorafshan et al., 2019, Dorafshan et al., 2019)

wing sensillum | ectopic (with ash1²²)

(Dorafshan et al., 2019)

Detailed Description

Statement

Reference

ash1²¹/ash1²² transheterozygotes show a homeotic phenotype, with haltere towards wing and third leg towards second leg transformations, as well as partial transformation of abdominal segments 6 and 5 towards segments 5 and 4, which is visible from the partial loss of pigmentation on tergites 5 and 6 and appearance of bristles on sternite 6.

(Dorafshan et al., 2019)

ash1²¹/ash1²² adults show homeotic transformation: transformation of the third thoracic segment (T3) to second thoracic segment (T2), including partial transformation of haltere to wing, characterized by the appearance of bristles on the haltere, appearance of hypopleural bristles on T3, and the third leg to second leg transformation manifested by the appearance of apical and pre-apical bristles on the third leg; transformation of posterior abdominal segments to more anterior fate, visible by the partial loss of pigmentation in tergites 5.

(Dorafshan et al., 2019)

Few double heterozygotes with Ubx^abx-1, trx^el2 or brm² exhibit transformation of third leg to second leg identity and haltere to wing transformation.

(Tripoulas et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

ash1²²/ash1²¹ has homeotic | adult stage phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has visible | adult stage phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

ash1²²/ash1²¹ has haltere phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has metathoracic leg phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has wing | ectopic phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has mesothoracic leg | ectopic phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has adult abdominal segment 5 phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has adult abdominal segment 6 phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

ash1²²/ash1²¹ has adult abdominal segment 4 phenotype, non-suppressible by NSD^ds46/NSD^ds46

(Dorafshan et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

(Tripoulas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

VU215

ash1²¹

(Dorafshan et al., 2019, Dorafshan et al., 2019)

dash²¹

(Lindsley and Zimm, 1992)

dash^VU215

(Shearn et al., 1971)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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