FlyBase Allele Report: Dmel\Antp[B]

General Information

Symbol

Dmel\Antp^B

Species

D. melanogaster

Name

of Bacon

FlyBase ID

FBal0000580

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Abbott and Kaufman, 1986)

gain of function allele

loss of function allele

(McKenna et al., 1989)

Mutagen

X ray

(Scott et al., 1983)

Progenitor genotype

Caused by aberration

In(3R)Antp^B

Cytology

Description

Inversion breakpoint is 10.5kb upstream of the P2 cap site.

(Boulet and Scott, 1988)

Distal inversion breakpoint is at map position +138.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antenna

(Yazdani et al., 2008, Cribbs et al., 1995, McKenna et al., 1989, Abbott and Kaufman, 1986, Scott et al., 1983, Lewis et al., 1980, Duncan and Kaufman, 1975)

leg | ectopic

(Yazdani et al., 2008)

mesothoracic leg | ectopic

(Cribbs et al., 1995)

Detailed Description

Statement

Reference

Heterozygous adults show transformation of antenna to leg.

(Yazdani et al., 2008)

Partial transformation of antennae into legs. Flies exhibit diminished chemosensory jump behaviour to ethyl acetate but no change in the jump response to a visual stimulus.

(McKenna et al., 1989)

Homeotic transformation of antennae to mesothoracic legs.

(Abbott and Kaufman, 1986)

Enhanced by ph-d².

(Dura et al., 1985)

Antennae to leg transformation.

(Scott et al., 1983)

Transformation of antenna to prothoracic leg identity.

(Lewis et al., 1980)

Antenna are leg-like.

(Duncan and Kaufman, 1975)

Lethal with Antp^Yu, Antp⁴⁹, Antp⁵⁰, and Scr.

(Hannah and Stromnaes, 1955)

Antenna partially leglike but less extreme than Antp^Yu and may overlap wild type. Enhanced by Pc. Enhanced by Pc². Enhanced by ss^a. Antp^B ss^a/+ ss^a has virtually complete antennal leg including coxa, tibia, femur, and tarsus but no sex comb in the male (B. Holloway, cited in FBrf0020044). RK3A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Antp^B has visible | dominant phenotype, enhanceable by Glut4EF^d.UAS/Scer\GAL4^NP7418

(Yazdani et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^B has antenna phenotype, enhanceable by Glut4EF^d.UAS/Scer\GAL4^NP7418

(Yazdani et al., 2008)

Antp^B has leg | ectopic phenotype, enhanceable by Glut4EF^d.UAS/Scer\GAL4^NP7418

(Yazdani et al., 2008)

Antp^B has phenotype, enhanceable by art¹

(Ouweneel, 1970)

Other

Statement

Reference

Antp^B, pb^hs.PB has antenna phenotype

(Cribbs et al., 1995)

Antp^B, pb^hs.PB has maxillary palp | ectopic phenotype

(Cribbs et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of antenna-to-leg transformation seen in Antp^B heterozygotes is increased by expression of Glut4EF^d.Scer\UAS under the control of Scer\GAL4^{Glut4EF-NP7418}.

(Yazdani et al., 2008)

Homeotic transformation of antennae to T2 leg seen in Antp^B flies can be redirected by pb^hs.PB from ectopic leg to maxillary palp.

(Cribbs et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

3511

In(3R)Antp^B, Antp^B Ubx^bx-34e Ubx^bxd-121/TM1

2229

In(3R)Antp^B, Antp^B p^p Ubx^bx-1/TM2, p^p

Kyoto

101665

In(3R)Antp^B, Antp^B / TM1, Me¹ kni^ri-1 Sb^sbd-l ?

Notes on Origin

Discoverer

Bacon, July 1950.

Comments

The wing positioning defects in In(3R)Antp^B flies were previously attributed to an effect on Antp (FBrf0107412 and FBrf0155711), however, FBrf0204343 demonstrates that these phenotypes are instead due to an effect on Glut4EF, which is also disrupted by the In(3R)Antp^B chromosome.

(Yazdani et al., 2008)

FlyBase curator comment: FBrf0155711 attributes the wing positioning defects in In(3R)Antp^B flies to an effect on Antp. However, FBrf0204343 demonstrates that the Glut4EF gene is also disrupted by the In(3R)Antp^B chromosome, and that the wing positioning defects seen are instead due to an effect on Glut4EF.

(Gutierrez et al., 2003)

FlyBase curator comment: FBrf0107412 attributes the wing positioning defects in In(3R)Antp^B flies to an effect on Antp. However, FBrf0204343 demonstrates that the Glut4EF gene is also disrupted by the In(3R)Antp^B chromosome, and that the wing positioning defects seen are instead due to an effect on Glut4EF.

(Vazquez et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Antp^B

(Riede, 2004)

Name Synonyms

of Bacon

Secondary FlyBase IDs

References (22)

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