FlyBase Allele Report: Dmel\Antp[Scx]

General Information

Symbol

Dmel\Antp^Scx

Species

D. melanogaster

Name

FlyBase ID

FBal0000617

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

?{}Antp^Scx

Carried in Construct

Also Known As

Scx

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Scott et al., 1983)

Progenitor genotype

Associated Insertion(s)

?{}Antp^Scx

Cytology

Polytene chromosomes normal.

(Scott et al., 1983, Kaufman et al., 1980, Lewis et al., 1980)

Description

Four genetic properties are associated with the "Scx" chromosome (which has an insertion of repetitive DNA very close to the Antp P1 promoter); loss of Antp P1 promoter function, loss of Antp P2 promoter function, derepression of the Scr promoter in cis (on the mutant chromosome) and derepression of the Scr promoter in trans (on the homologous chromosome). The ectopic sex comb teeth on the second and third legs seen in "Scx" heterozygotes are due to misexpression of Scr in cis and in trans.

(Southworth and Kennison, 2002)

Insertion of 3kb, transposon unknown, at map position +199.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Antp¹)

(Southworth and Kennison, 2002)

lethal (with Antp²³)

(Southworth and Kennison, 2002)

lethal | recessive

(Scott et al., 1983, Kaufman et al., 1980, Duncan and Kaufman, 1975)

visible | dominant

visible | dominant | homeotic

(Sinclair et al., 1984)

visible | homeotic

(Scott et al., 1983, Kaufman et al., 1980)

Phenotype Manifest In

leg

(Sinclair et al., 1984)

mesothoracic leg

(Scott et al., 1983, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)

metathoracic leg

(Scott et al., 1983, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)

sex comb

(Kaufman et al., 1980)

sex comb | ectopic

(Sinclair et al., 1984, Duncan and Kaufman, 1975)

Detailed Description

Statement

Reference

Suppressed by a duplication carrying Pc⁺.

(Kennison and Russell, 1987)

Enhanced by ph-d².

(Dura et al., 1985)

Between 44.4% and 61.5% of heterozygous males have an extra sex combs phenotype.

(Sinclair et al., 1984)

Partial transformation of second and third legs into first legs.

(Scott et al., 1983)

Sex comb teeth are produced on the basitarsus of all six legs (transformation of meso- and metathoracic into prothoracic legs).

(Kaufman et al., 1980)

Transformation of meso- and metathoracic legs to prothoracic leg identity.

(Lewis et al., 1980)

Transformation of meso- and metathoracic leg to prothoracic leg identity.

(Lewis et al., 1980)

Sex combs are present on all male legs.

(Duncan and Kaufman, 1975)

Sex combs may be present on all six legs of male. At least one extra sex comb present in 75-90% of males. Third pair of legs less often affected than second. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Antp^Scx, Pc²¹ has visible phenotype, suppressible by Nsf2^urd-2/urd[+]

(Kennison and Tamkun, 1988)

Antp^Scx, Pc²¹ has visible phenotype, suppressible by vtd¹/vtd[+]

(Kennison and Tamkun, 1988)

Antp^Scx has visible | dominant | homeotic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Antp^Scx has visible | dominant | homeotic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

Other

Statement

Reference

Antp^Scx, Pc²¹ has visible phenotype

(Kennison and Tamkun, 1988)

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^Scx has phenotype, enhanceable by Pcl¹

(Duncan, 1982)

Antp^Scx has phenotype, enhanceable by ph-d²

(Kaufman et al., 1980)

Antp^Scx has phenotype, enhanceable by Ubx^unspecified

(Hannah-Alava, 1964)

Antp^Scx has phenotype, enhanceable by Pc^unspecified

(Hannah-Alava, 1964)

Suppressed by

Statement

Reference

Antp^Scx, Pc²¹ has sex comb phenotype, suppressible by Nsf2^urd-2/urd[+]

(Kennison and Tamkun, 1988)

Antp^Scx, Pc²¹ has sex comb phenotype, suppressible by vtd¹/vtd[+]

(Kennison and Tamkun, 1988)

Antp^Scx, Pc² has sex comb phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

Antp^Scx has phenotype, suppressible by Scr^E1

(Kennison and Tamkun, 1988)

Antp^Scx has phenotype, suppressible by Scr^E2

(Kennison and Tamkun, 1988)

Antp^Scx has phenotype, suppressible by Scr^E3

(Kennison and Tamkun, 1988)

Antp^Scx has sex comb | ectopic phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Antp^Scx has sex comb | ectopic phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

Antp^Scx has leg phenotype, suppressible by M(2)56F^unspecified

(Sinclair et al., 1984)

Antp^Scx has leg phenotype, suppressible by Df(3L)M(3)LS4

(Sinclair et al., 1984)

Other

Statement

Reference

Antp^Scx, Pc²¹ has sex comb phenotype

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of Antp^Scx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not.

(Kennison and Tamkun, 1988)

The penetrance of the extra sex comb phenotype is suppressed by M(2)56F^unspecified or Df(3L)M(3)LS4.

(Sinclair et al., 1984)

Antp^Scx/Pc^unspecified more extreme than Antp^Scx/+; male usually has large sex comb on all six legs. Expression of Antp^Scx/+ enhanced in males that are also heterozygous for alleles of Ubx including bx- and bxd-class alleles. Furthermore, with bx and bxd alleles, the enhancement is greater if mutants are in coupling rather than repulsion, but compounds with other Ubx alleles show no phase difference.

(Hannah-Alava, 1964)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Antp²³

(Southworth and Kennison, 2002)

Antp¹

(Southworth and Kennison, 2002)

Antp⁴⁹

(Lindsley and Grell, 1968)

Antp^Yu

(Hannah and Stromnaes, 1955)

Antp^B

(Hannah and Stromnaes, 1955)

Antp⁵⁰

Antp⁴⁹

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

3407

ru¹ hry¹ st¹ cp¹ in¹ kni^ri-1 Antp^Scx p^p cu¹ e¹/TM3, Sb¹

Kyoto

106755

ru¹ hry¹ st¹ kni^ri-1 Antp^Scx p^p e^s/TM3, Sb Ser

107032

ru¹ hry¹ st¹ cp¹ in¹ kni^ri-1 Antp^Scx p^p cu¹ e¹/TM3, Sb¹

101762

(th¹) (st¹) (cp¹) (in¹ kni^ri-1 Antp^Scx p^p Ubx¹ / TM1, Me¹ kni^ri-1 Sb^sbd-l

Notes on Origin

Discoverer

Hannah, Feb. 1953.

Comments

Weak dominant allele.

FlyBase curator comment: data in FBrf0149025 indicates that the "Scx" mutant chromosome (which has an insertion of repetitive DNA very close to the Antp P1 promoter) affects both Antp and Scr activity and that the ectopic sex combs phenotype of the chromosome is most likely due to an effect on Scr rather than on Antp.

(Sinclair et al., 1984, Kaufman et al., 1980, Hannah-Alava, 1964)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Antp^Scx

Scx

(Dura et al., 1985, Sinclair et al., 1984, Duncan, 1982, Kaufman et al., 1980)

Scx¹

(Scott et al., 1983)

scx

(Simon et al., 1992)

Name Synonyms

Extra sex comb

(Duncan and Kaufman, 1975)

Sex combs extra

Secondary FlyBase IDs

References (17)

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