Papayannopoulos, V., Tomlinson, A., Panin, V.M., Rauskolb, C., Irvine, K.D. (1998). Dorsal-ventral signaling in the Drosophila eye.  Science 281(5385): 2031--2034.

FBrf0104775

Research paper

The development of the Drosophila eye has served as a model system for investigations of tissue patterning and cell-cell communication; however, early eye development has not been well understood. The results presented here indicate that specialized cells are established along the dorsal-ventral midline of the developing eye by Notch-mediated signaling between dorsal and ventral cells, and that Notch activation at the midline plays an essential role both in promoting the growth of the eye primordia and in regulating eye patterning. These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends to Drosophila eyes.