FlyBase Gene Report: Dmel\Sec15

FB2024_04 , released June 25, 2024

FB2024_04 , released June 25, 2024

Gene: Dmel\Sec15

General Information

Symbol

Dmel\Sec15

Species

D. melanogaster

Name

Secretory 15

Annotation Symbol

CG7034

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266674

Gene Model Status

Stock Availability

8 publicly available

Gene Summary

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProt, Q9VDE6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:21,105,046..21,107,972 [-]

Recombination map

3-70

RefSeq locus

NT_033777 REGION:21105046..21107972

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables small GTPase binding

inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790

(Langevin et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (11 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Mehta et al., 2005)

involved_in border follicle cell migration

inferred from mutant phenotype

(Assaker et al., 2010)

involved_in chaeta development

inferred from mutant phenotype

(Jafar-Nejad et al., 2005)

involved_in endocytic recycling

inferred from mutant phenotype

(Jafar-Nejad et al., 2005, Langevin et al., 2005)

involved_in phototaxis

inferred from mutant phenotype

(Mehta et al., 2005)

involved_in protein localization to plasma membrane

inferred from mutant phenotype

(Langevin et al., 2005)

involved_in vesicle-mediated transport

inferred from mutant phenotype

(Jones et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000294823

(GO Reference Genome Project, 2011-)

involved_in Golgi to plasma membrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000294823

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR007225

(InterPro Project Members, 2004-)

involved_in vesicle tethering involved in exocytosis

inferred from electronic annotation with InterPro:IPR007225

(InterPro Project Members, 2004-)

inferred by curator from GO:0000145

(Stuart et al., 2007)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Mehta et al., 2005)

located_in cytoplasmic vesicle

inferred from direct assay

(Jafar-Nejad et al., 2005, Mehta et al., 2005)

located_in endosome

inferred from direct assay

(Tong et al., 2011, Jafar-Nejad et al., 2005)

part_of exocyst

inferred from direct assay

(Stuart et al., 2007, Langevin et al., 2005)

located_in recycling endosome

inferred from direct assay

(Langevin et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of exocyst

inferred from biological aspect of ancestor with PANTHER:PTN000294823

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the SEC15 family. (Q9VDE6)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

EXOCYST -: The exocyst complex is composed of eight proteins. It is involved tethering secretory vesicles to the plasma membrane and may regulate other aspects of intracellular trafficking such as SNARE assembly, cytokinesis and endocytic recycling. The exocyst complex is a member of the Complex Associated with Tethering Containing Helical Rods (CATCHR) family. (Adapted from FBrf0219543).

Protein Function (UniProtKB)

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

(UniProt, Q9VDE6)

Summary (Interactive Fly)

functions in polarized exocytosis/secretion - involved in targeting photoreceptor axons that involves localization of specific cell adhesion and signaling molecules

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Sec15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VDE6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

2A2F

Comments on Gene Model

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0084034

2799

766

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0083436

88.7

766

6.37

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8 (By similarity). Interacts with RAB3, RAB8, RAB11 and RAB27.

(UniProt, Q9VDE6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

2A2F

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VDE6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec15 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec15_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

• endosome

(Tong et al., 2011)

pharate adult stage P8

ommatidial precursor cluster

(Wu et al., 2005)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Sec15 protein labels the endosome of lamina cells in pupa.

(Tong et al., 2011)

Rab11 and Sec15 partially colocalize in the developing rhabdomeres.

(Wu et al., 2005)

Marker for

(Tong et al., 2011)

Subcellular Localization

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Mehta et al., 2005)

located_in cytoplasmic vesicle

inferred from direct assay

(Jafar-Nejad et al., 2005, Mehta et al., 2005)

located_in endosome

inferred from direct assay

(Tong et al., 2011, Jafar-Nejad et al., 2005)

part_of exocyst

inferred from direct assay

(Stuart et al., 2007, Langevin et al., 2005)

located_in recycling endosome

inferred from direct assay

(Langevin et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sec15 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sec15

View exonic expression by tissue for Dmel\Sec15

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42499/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266674

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038856

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266674

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7034

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sec15

Transgenic constructs containing regulatory region of Sec15

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

(Mehta et al., 2005)

(Ryder, 2004.4.26)

Gene not duplicated in

(Mehta et al., 2005)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^grh.D4

Sec15^JF02649

lethal - all die before end of larval stage (with Sec15¹)

Sec15³

lethal - all die before end of larval stage (with Sec15²)

Sec15³

lethal - all die before end of larval stage (with Sec15³)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Sec15^GD12109

lethal - all die before end of second instar larval stage (with Df(3R)e-R1)

Sec15²

lethal - all die before end of second instar larval stage | recessive

Sec15³

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sec15^GD12109

viable, with Scer\GAL4^Mef2.PR

Sec15^GD12109

viable, with Scer\GAL4^tin.CΔ4

Sec15^GD12109

Other Phenotypes

Allele

abnormal developmental rate | larval stage, with Scer\GAL4^phtm.PO

abnormal flight, with Scer\GAL4^Mef2.PR

Sec15^GD12109

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

abnormal neuroanatomy | larval stage, with Scer\GAL4^VGlut-OK371

Sec15^KK101708

abnormal neuroanatomy | somatic clone

abnormal neurophysiology | larval stage, with Scer\GAL4^elav.PU

abnormal neurophysiology | larval stage, with Scer\GAL4^VGlut-OK371

Sec15^KK101708

abnormal neurophysiology | somatic clone

abnormal phototaxis | somatic clone

decreased body size | larval stage, with Scer\GAL4^grh.D4

Sec15^JF02649

some die during larval stage, with Scer\GAL4^phtm.PO

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sec15^GD12109

some die during second instar larval stage (with Df(3R)e-R1)

Sec15²

some die during second instar larval stage | recessive

Sec15³

some die during third instar larval stage (with Sec15¹)

Sec15³

some die during third instar larval stage (with Sec15²)

Sec15³

some die during third instar larval stage (with Sec15³)

visible | larval stage, with Scer\GAL4^grh.D4

Sec15^JF02649

Phenotype manifest in

Allele

adult optic lobe | somatic clone

Sec15¹

axon & photoreceptor cell R7 | somatic clone

Sec15¹

axon & photoreceptor cell R8 | somatic clone

Sec15¹

border follicle cell, with Scer\GAL4^c306

Sec15^VDRC.cUa

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav.PU

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^VGlut-OK371

Sec15^KK101708

embryonic/larval posterior spiracle | larval stage, with Scer\GAL4^grh.D4

Sec15^JF02649

embryonic/larval tracheal dorsal trunk | first instar larval stage, with Scer\GAL4^grh.D4

Sec15^JF02649

eo neuron & mesothoracic tergum & pupa | somatic clone | supernumerary

Sec15³

extracellular vesicle | decreased number | larval stage, with Scer\GAL4^elav.PU

Sec15^KK101708

macrochaeta & mesothoracic tergum | somatic clone

Sec15³

medulla | somatic clone

Sec15¹

nerve terminal & optic cartridge | somatic clone

Sec15¹

nerve terminal & optic cartridge | somatic clone | cell autonomous

Sec15²

NMJ bouton | increased number | larval stage, with Scer\GAL4^elav.PU

NMJ bouton | increased number | larval stage, with Scer\GAL4^VGlut-OK371

Sec15^KK101708

presynaptic active zone | larval stage, with Scer\GAL4^elav.PU

presynaptic active zone | larval stage, with Scer\GAL4^VGlut-OK371

Sec15^KK101708

thecogen cell & mesothoracic tergum & pupa | somatic clone

Sec15³

tormogen cell & mesothoracic tergum & pupa | somatic clone

Sec15³

type I bouton | larval stage, with Scer\GAL4^elav.PU

wing hair | pupal stage, with Scer\GAL4^dpp.blk1, Scer\GAL80^ts.αTub84B

Sec15^KK101708

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

13 of 14

Yes

Yes

13 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

13 of 14

Yes

Yes

12 of 14

No

Yes

Mus musculus (laboratory mouse) (2)

13 of 14

Yes

Yes

13 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (4)

8 of 13

Yes

Yes

7 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

Danio rerio (Zebrafish) (2)

13 of 14

Yes

Yes

12 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

14 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP006648

12 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (2)

13 of 13

Yes

Yes

12 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

11 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

11 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sec15. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

EXOC6B; exocyst complex component 6B

model of spondyloepimetaphyseal dysplasia with joint laxity type 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS

(Chabu and Xu, 2014)

exacerbates muscular dystrophy

modeled by Dg^O86

(Yatsenko et al., 2021)

ameliorates nervous system disease

modeled by Atpα^CJ10

(Talsma et al., 2014)

ameliorates cancer

modeled by Ras85D^V12.UAS

(Chabu and Xu, 2014)

ameliorates cancer

modeled by Ras85D^V12.UAS

(Chabu and Xu, 2014)

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EXOC6B; exocyst complex component 6B

13 of 14

SPONDYLOEPIMETAPHYSEAL DYSPLASIA WITH JOINT LAXITY, TYPE 3; SEMDJL3

spondyloepimetaphyseal dysplasia with joint laxity type 3

EXOC6; exocyst complex component 6

13 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Mao et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot

(Giagtzoglou et al., 2012)

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Chan et al., 2021)

pull down, western blot, autoradiography, anti tag western blot, anti bait coimmunoprecipitation

(Chan et al., 2021, Langevin et al., 2005, Wu et al., 2005)

pull down, western blot

(Wu et al., 2005)

pull down, western blot

(Wu et al., 2005)

pull down, western blot

(Wu et al., 2005)

anti bait coimmunoprecipitation, western blot

(Peng et al., 2015)

anti tag coimmunoprecipitation, western blot

(Langevin et al., 2005)

anti bait coimmunoprecipitation, western blot

(Langevin et al., 2005)

anti bait coimmunoprecipitation, western blot

(Chabu and Xu, 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chabu and Xu, 2014)

suppressible

(Jafar-Nejad et al., 2005)

suppressible

(Kang et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Atienza-Manuel et al., 2021)

suppressible

(Michel et al., 2011)

enhanceable

(Zhu et al., 2021)

enhanceable

(Kang et al., 2024)

enhanceable

(Balakireva et al., 2006)

suppressible

(Chabu and Xu, 2014)

suppressible

(Chabu and Xu, 2014)

External Data

Subunit Structure (UniProtKB)

The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8 (By similarity). Interacts with RAB3, RAB8, RAB11 and RAB27.

(UniProt, Q9VDE6 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266674

MIST (protein-protein) - An integrated Molecular Interaction Database

42499

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-70

Cytogenetic map

Sequence location

3R:21,105,046..21,107,972 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93B12-93B12

Limits computationally determined from genome sequence between P{PZ}Atpα⁰¹¹⁶⁴ and P{PZ}mod(mdg4)⁰⁷⁰³⁸&P{lacW}mod(mdg4)^L3101

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-70

(FlyBase, 2016)

3-73.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

39685

w^*; P{UAS-GFP.Sec15}2/CyO

27499

y¹ v¹; P{TRiP.JF02649}attP2

24889

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}82B Sec15¹/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb¹

24890

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}82B Sec15²/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb¹

HMJ23977

y¹ v¹; P{TRiP.HMJ23977}attP40/CyO

v105126

P{KK101708}VIE-260B

v35161

w¹¹¹⁸; P{GD12109}v35161

v318013

PBac{fTRG00028.sfGFP-TVPTBF}VK00033

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (147)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE55430

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266674

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA directed against sec15 show normal binding but significantly decreased internalization of E.coli and S.aureus in a phagocytosis assay.

(Stuart et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Sec15 sec15

(FlyBase, 1992-)

Additional comments

FlyBase curator comment: the insertion in the "d11525" Exelixis line (P{XP}rtet^d11525) was originally assigned to the sec15 gene in FBrf0179797, resulting in the "sec15^d11525" (FBal0158687) allele. However, FBrf0184340 shows that the insertion is actually within rtet.

(Bloomington Drosophila Stock Center, 2004.11.6)

Nomenclature History

Source for database identify of

Source for identity of: Sec15 sec15

(FlyBase, 2009-)

Source for identity of: sec15 CG7034

(Verstreken and Bellen, 2000.9.4)

Nomenclature comments

Etymology

Named "Sec15" after the S. cerevisiae ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

3R41

(Mehta et al., 2005)

CG7034

(National Institute of Genetics Fly Stocks, 2023-, Laffafian and Tepass, 2019, Hosono et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, Whitfield et al., 2002)

Sec15

(Dennis et al., 2024, Ascencio et al., 2023, Sanal et al., 2023, Swope et al., 2022, Tanasic et al., 2022, van de Leemput et al., 2022, Wang et al., 2022, Atienza-Manuel et al., 2021, Chan et al., 2021, Harnish et al., 2021, Ricolo et al., 2021, Yatsenko et al., 2021, Zhu et al., 2021, Wen et al., 2020, Bhuin and Roy, 2019, Chaudhary and Boutros, 2019, Laffafian and Tepass, 2019, Mao et al., 2019, Salazar and Yamamoto, 2018, Wang et al., 2018, Roman-Fernandez and Bryant, 2016, Peng et al., 2015, Schweisguth, 2015, Yamanaka et al., 2015, Jones et al., 2014, Guichard et al., 2013, Bier and Guichard, 2012, Gault et al., 2012, Giagtzoglou et al., 2012, Heider and Munson, 2012, Tong et al., 2011, Benhra et al., 2010, Williamson et al., 2010, Gallagher and Knoblich, 2006, Somers and Chia, 2005, Wu et al., 2005, Littleton, 2000)

Sec15p

(Littleton, 2000)

dsec15

(Lloyd et al., 2000)

Name Synonyms

Sec15 ortholog

Secretory 15

Secondary FlyBase IDs

FBgn0266614
FBgn0038856

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42499

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VDE6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VDE6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VDE6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42499/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266674

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266674

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7034

MARRVEL_MODEL - MARRVEL (model organism gene)

42499

PDB - An information portal to biological macromolecular structures

2A2F

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266674

DroID - A comprehensive database of gene and protein interactions.

FBgn0266674

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec15_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038856

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266674

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7034

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0266674

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011021

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

42499

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (108)