l(2)44DEa, dAcsl, l(2)k05304, Fatty acyl CoA synthetase, lethal (2) 44DEa
regulates fatty acid metabolism - modifies the composition of fatty acids and membrane lipid - inhibits neuromuscular junction growth - facilitates Rab11-dependent receptor recycling - regulates axonal transport of synaptic vesicles
Please see the JBrowse view of Dmel\Acsl for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Acsl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Acsl protein is ubiquitously distributed in early embryos.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Acsl in JBrowse2-59
2-57.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase Curator comment: 'Acsl' identified as 'FCS' by BLASTing the 'FCS' primer sequences given in the Supplementary Methods.
11 alleles of l(2)SH0465 recovered in a P-insertion screen.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
l(2)44DEa may be involved in keeping sister chromatids together or stabilizing the microtubule contact with centromeres.
Source for merge of: l(2)05847 l(2)k05304
Source for merge of: l(2)44DEa CG8732
Source for merge of: l(2)44DEa anon-WO0172774.173
Source for merge of: Acsl l(2)SH0465
Source for merge of l(2)44DEa anon-WO0172774.173 was sequence comparison ( date:051113 ).
Source for identity of: Acsl l(2)44DEa