CAP, acu, l(2)06955, act up, Acap
cyclase-associate protein homolog - actin binding protein - required to prevent actin filament polymerization in the eye disc - negatively regulate actin filament assembly
Please see the JBrowse view of Dmel\capt for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\capt using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\capt in JBrowse2-2
2-1.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Mutant show altered F-actin and oocyte polarity during oogenesis.
capt organises the polarised distribution of F-actin and mRNAs during oogenesis.
capt is required to prevent excessive polymerisation of actin filaments in the eye disc. It is also required for cells to change shape in the morphogenetic furrow and prevents premature neuronal differentiation in the eye disc.
capt is required for cells to constrict apically in the morphogenetic furrow in the eye disc and is also required to prevent premature neuronal differentiation.
Identification: identified as a mutation that affects both the actin cytoskeleton and oocyte polarity in female germline clones.
capt helps control the global distribution of actin filaments in cells.
Loss of capt function in clones results in the dramatic re-organisation of actin filaments in many tissues, leading to the loss of some actin structures and the accumulation of massive clumps of F-actin at characteristic ectopic sites.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. capt is required for germ cell viability or early oogenesis.
Source for merge of: capulet l(2)06955
Source for merge of: capt acu
Source for merge of: capt Acap
Source for merge of: capt punc
Source for merge of: capt CG5074
Annotations CG5061 and CG5074 merged as CG33979 in release 4.3 of the genome annotation.
Source for identity of: BcDNA:LD24380 CG5061
The gene is named "act up" for its effect on actin.
