FlyBase Gene Report: Dmel\zuc

General Information

Symbol

Dmel\zuc

Species

D. melanogaster

Name

zucchini

Annotation Symbol

CG12314

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261266

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

zucchini (zuc) encodes a member of the phospholipase D superfamily. It is anchored in the outer mitochondrial membrane and functions in the processing of primary piRNA transcripts through its endonuclease activity. zuc depletion causes sterility, transposon de-repression and accumulation of piRNA cluster transcripts. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MitoPLD

Key Links

Genomic Location

Cytogenetic map

33B5-33B5

Sequence location

2L:11,988,735..11,989,882 [-]

Recombination map

2-45

RefSeq locus

NT_033779 REGION:11988735..11989882

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cardiolipin hydrolase activity

inferred from direct assay

(Huang et al., 2011)

enables RNA endonuclease activity, producing 5'-phosphomonoesters

inferred from mutant phenotype

(Hayashi et al., 2016)

inferred from direct assay

(Nishimasu et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables RNA endonuclease activity, producing 5'-phosphomonoesters

inferred from biological aspect of ancestor with PANTHER:PTN000478646

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in dorsal appendage formation

inferred from high throughput mutant phenotype

(Schupbach and Wieschaus, 1991)

involved_in oocyte karyosome formation

inferred from mutant phenotype

(Ghabrial et al., 1998)

involved_in oogenesis

inferred from high throughput mutant phenotype

(Schupbach and Wieschaus, 1991)

involved_in piRNA processing

inferred from mutant phenotype

(Akkouche et al., 2017, Nishimasu et al., 2012)

inferred from mutant phenotype

(Saito et al., 2010)

involved_in primary piRNA processing

inferred from mutant phenotype

(Yamashiro et al., 2020, Hayashi et al., 2016, Czech et al., 2013)

involved_in regulatory ncRNA-mediated gene silencing

inferred from mutant phenotype

(Pane et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in oogenesis

traceable author statement

(van Eeden and St. Johnston, 1999)

involved_in piRNA processing

inferred from biological aspect of ancestor with PANTHER:PTN000478647

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

is_active_in cytoplasmic side of mitochondrial outer membrane

inferred from direct assay

(Ge et al., 2019, Munafò et al., 2019, Huang et al., 2014, Huang et al., 2011)

is_active_in mitochondrion

inferred from direct assay

(Hayashi et al., 2016)

located_in mitochondrion

inferred from direct assay

(Huang et al., 2011, Saito et al., 2010)

located_in P granule

inferred from direct assay

(Pane et al., 2007)

NOT located_in P granule

inferred from direct assay

(Huang et al., 2011, Saito et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000478647

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED PHOSPHORIC DIESTER HYDROLASES

UNCLASSIFIED RNA ENDONUCLEASES

Protein Family (UniProt)

Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily. (Q9VKD7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED PHOSPHORIC DIESTER HYDROLASES -: This group comprises phosphoric diester hydrolases that do not classify under other groups in FlyBase.
UNCLASSIFIED RNA ENDONUCLEASES -: This group comprises endoribonucleases that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.

(UniProt, Q9VKD7)

Summary (Interactive Fly)

nuclease that functions in germline RNAi processes, required in dorso-ventral patterning pathway - required early during oogenesis for the translational silencing of osk mRNA and at later stages for proper expression of the Grk protein - regulates telomere-specific transposable elements

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\zuc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VKD7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

zuc-RA

FBtr0080316

NM_135686

1148

253

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

zuc-PA

FBpp0079900

28.5

253

9.53

Q9VKD7

NP_609530

AAF53139

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).

(UniProt, Q9VKD7)

Domain

In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.

(UniProt, Q9VKD7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VKD7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zuc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

zuc_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.36

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval visceral muscle cell

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in cytoplasmic side of mitochondrial outer membrane

inferred from direct assay

(Ge et al., 2019, Munafò et al., 2019, Huang et al., 2014, Huang et al., 2011)

is_active_in mitochondrion

inferred from direct assay

(Hayashi et al., 2016)

located_in mitochondrion

inferred from direct assay

(Huang et al., 2011, Saito et al., 2010)

located_in P granule

inferred from direct assay

(Pane et al., 2007)

NOT located_in P granule

inferred from direct assay

(Huang et al., 2011, Saito et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\zuc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\zuc

View exonic expression by tissue for Dmel\zuc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261266

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34609/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261266

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032389

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261266

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12314

Flygut - An atlas of the Drosophila adult midgut

FBgn0261266

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of zuc

Transgenic constructs containing regulatory region of zuc

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)Exel6031

(Ryder, 2004.4.26)

Df(2L)prd1.7

(Schupbach and Wieschaus, 1991)

Df(2L)Prl

(Chen et al., 2021, Schupbach and Wieschaus, 1991)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

zuc^GD6746

viable, with Scer\GAL4^tin.CΔ4

zuc^GD6746

Sterility

Allele

female sterile

female sterile, with Scer\GAL4^nanos.PG

fertile

male semi-fertile, with Scer\GAL4^{VP16.nanos.UTR}

zuc^GL00111

Other Phenotypes

Allele

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

Phenotype manifest in

Allele

dorsal appendage

zuc^RS49

dorsal appendage (with Df(2L)Prl)

egg

zuc^RS49

egg (with Df(2L)Prl)

egg chamber

zuc^unspecified

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

karyosome

zuc^unspecified

mitochondrion, with Scer\GAL4^Cg.PA

zuc^{DN.UAS.Tag:HA}

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

oocyte

zuc^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\PLD6

11 of 14

Yes

Hsap\FAM83D

1 of 14

Yes

Hsap\PGS1

1 of 14

Hsap\PLD1

1 of 14

Hsap\PLD2

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Pld6

11 of 14

Yes

Rnor\Fam83d

1 of 14

Yes

Rnor\Pgs1

1 of 14

Rnor\Pld1

1 of 14

Rnor\Pld2

1 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Pld6

10 of 14

Yes

Mmus\Fam83d

1 of 14

Yes

Mmus\Fam83e

1 of 14

Yes

Mmus\Pgs1

1 of 14

Mmus\Pld1

1 of 14

Mmus\Pld2

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\pld6

8 of 13

Yes

Xtro\liph

1 of 13

Danio rerio (Zebrafish) (4)

Drer\pld6

11 of 14

Yes

Drer\pgs1

1 of 14

Drer\pld1b

1 of 14

Drer\pld2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\E04F6.4

1 of 14

Yes

Cele\pgs-1

1 of 14

Yes

Cele\pld-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP006233

11 of 12

Yes

Agam\AgaP_AGAP002662

1 of 12

Agam\AgaP_AGAP010687

1 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\PLDALPHA1

1 of 13

Yes

Atha\PLDALPHA2

1 of 13

Yes

Atha\PLDALPHA3

1 of 13

Yes

Atha\PLDBETA1

1 of 13

Yes

Atha\PLDBETA2

1 of 13

Yes

Atha\PLDDELTA

1 of 13

Yes

Atha\PLDEPSILON

1 of 13

Yes

Atha\PLDGAMMA1

1 of 13

Yes

Atha\PLDGAMMA2

1 of 13

Yes

Atha\PLDGAMMA3

1 of 13

Yes

Atha\PLDP1

1 of 13

Yes

Atha\PLDP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\PGS1

1 of 13

Yes

Scer\SPO14

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pld1

1 of 12

Yes

Spom\SPBP18G5.02

1 of 12

Yes

Escherichia coli (enterobacterium) (4)

Ecol\clsA

1 of 11

Yes

Ecol\clsB

1 of 11

Yes

Ecol\clsC

1 of 11

Yes

Ecol\pssA

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:zuc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

PGS1

1 of 13

Pld

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLD6; phospholipase D family member 6

11 of 14

614960

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

zuc

anti tag coimmunoprecipitation, anti tag western blot, protein cross-linking with a bifunctional reagent, confirmation by molecular weight

(Munafò et al., 2019, Zhang et al., 2016)

zuc - AGO3

anti tag coimmunoprecipitation, western blot

(Huang et al., 2014)

zuc - Miga

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2016)

zuc - armi

anti tag coimmunoprecipitation, protein cross-linking with a bifunctional reagent, western blot, anti bait coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Ge et al., 2019, Ishizu et al., 2019)

zuc - aub

anti tag coimmunoprecipitation, anti tag western blot

(Pane et al., 2007)

zuc - piwi

anti tag coimmunoprecipitation, anti tag western blot

(Haase et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

RanGAP

enhanceable

zuc

(Gell and Reenan, 2013)

External Data

Subunit Structure (UniProtKB)

Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).

(UniProt, Q9VKD7 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261266

MIST (protein-protein) - An integrated Molecular Interaction Database

34609

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PA

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PA

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-45

Cytogenetic map

33B5-33B5

Sequence location

2L:11,988,735..11,989,882 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33B5-33B5

Limits computationally determined from genome sequence between P{EP}MESK1^EP980 and P{PZ}l(2)01810⁰¹⁸¹⁰&P{EP}CG6785^EP340

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-45

(FlyBase, 2016)

2-39.0

(Comeron et al., 2012)

2-[45]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18427

w¹¹¹⁸; PBac{WH}zuc^f01342

20310

y¹ w^67c23; P{EPgy2}zuc^EY11457

5120

zuc^RS49 cn¹ bw¹/CyO, l(2)DTS513¹

35227

y¹ sc^* v¹ sev²¹; P{TRiP.GL00111}attP2

35228

y¹ sc^* v¹ sev²¹; P{TRiP.GL00112}attP2

36742

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03002}attP40

Kyoto

108052

zuc^RS49 cn¹ bw¹/CyO, l(2)DTS513¹

NIG-Fly

HMS03002

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03002}attP40

VDRC

v110430

P{KK101658}VIE-260B

v48764

w¹¹¹⁸; P{GD6746}v48764/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD05365

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261266

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

CK01.1B.F8

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261266

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Haase et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

zuc is required for rasiRNA production in the female germline.

(Pane et al., 2007)

Mutations at the zuc locus cause defects in midoogenesis.

(Schupbach and Wieschaus, 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: zuc CG12314

(Pane et al., 2007)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG12314

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pane et al., 2007)

MitoPLD

(Xu et al., 2020, Zhang et al., 2016, Gupte, 2015, Muliyil and Narasimha, 2014, Muliyil et al., 2011)

ZUC

(Gamez et al., 2020, Kumar and Chen, 2012, Kolaczkowski et al., 2011)

zuc

(Venkei et al., 2023, Chen et al., 2021, Gonzalez et al., 2021, Ellison et al., 2020, Saint-Leandre et al., 2020, Ge et al., 2019, Kolliopoulou et al., 2019, Luhur et al., 2019, Wakisaka et al., 2019, Zhou et al., 2019, Huang et al., 2018, Kang et al., 2018, Ishizu et al., 2017, Rashpa et al., 2017, Blumenstiel et al., 2016, Fagegaltier et al., 2016, Ge et al., 2016, Kučerová et al., 2016, Zhang et al., 2016, Han et al., 2015, Hermant et al., 2015, Sienski et al., 2015, Yu et al., 2015, Huang et al., 2014, Lavrenov et al., 2014, Czech et al., 2013, Dennis et al., 2013, Gell and Reenan, 2013, Handler et al., 2013, Handler et al., 2013, Muerdter et al., 2013, Vagin et al., 2013, Olivieri et al., 2012, Vazquez-Pianzola and Suter, 2012, Handler et al., 2011, Klenov et al., 2011, Haase et al., 2010, Nagao et al., 2010, Olivieri et al., 2010, Saito et al., 2010, Todeschini et al., 2010, Malone et al., 2009, Robine et al., 2009, Saito et al., 2009, Chambeyron et al., 2008, Pane et al., 2007, Pane et al., 2007, Pane et al., 2007)

Name Synonyms

CG12314

Zucchini

(Santos et al., 2023, Cacchione et al., 2020, Sankaranarayanan and Weil, 2020, Thanh et al., 2020, Schmidt et al., 2019, Yamashiro and Siomi, 2018, Huang et al., 2017, Haase, 2016, Hayashi et al., 2016, Hirakata and Siomi, 2016, Castel and Martienssen, 2013, Mani and Juliano, 2013, Simkin et al., 2013, Nishimasu et al., 2012)

Zuchini

(Kelleher et al., 2020)

Secondary FlyBase IDs

FBgn0004056
FBgn0032389

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34609

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VKD7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VKD7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VKD7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261266

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34609/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261266

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261266

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12314

MARRVEL_MODEL - MARRVEL (model organism gene)

34609

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261266

DroID - A comprehensive database of gene and protein interactions.

FBgn0261266

DRSC - Results frm RNAi screens

FBgn0261266

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

zuc_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032389

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261266

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12314

Flygut - An atlas of the Drosophila adult midgut

FBgn0261266

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261266

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

34609

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PA

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PA

References (147)

The following external sites may use different assemblies or annotations than FlyBase.

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