PHD finger superfamily protein - a nucleolar protein required for small ribosomal subunit biogenesis - transcriptionally regulated by Myc which relays information from nutrient dependent signaling pathways to ribosomal gene expression - part of the Myc and CK2 regulatory networks for coordination of neuroblast growth and proliferation
Please see the JBrowse view of Dmel\mbm for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
May be phosphorylated in vivo by CkIIalpha. mbm and CkIIalpha colocalize to the nucleolus and mbm is phosphorylated in vitro by CkIIalpha.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mbm using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\mbm in JBrowseMaps meiotically to distal 2L.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
mbm mutants exhibit a striking sexual dimorphism, mushroom bodies of females are completely absent while those of males are reduced by 30%. All mutant are impaired in associative odour learning and memory.
mbm males display courtship behaviour similar to that of wild type males although courtship intensity is reduced. This suggests that mushroom bodies do not play an important role in male courtship behaviour.
Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.
All three mbm alleles, when heterozygous with Df(2L)al, lead to stronger mutant phenotypes than mutant homozygotes or heteroallelic combinations; mbmK1/mbmK7 causes a very weak (i.e., near normal) mushroom body defect. mbmK1 and mbmK7 are from stocks originally termed "Df(2L)netK1" and "Df(2L)netK7"; each of these turns out not to be a deletion, i.e. they appear to be cytologically normal, but the former is mutant for net, mbm and a vital gene, as is the latter, though the lethal here complements that on the K1 chromosome. In both of these stocks, the various abnormalities are separable by recombination. Isolation: Mutagenized second chromosome provided by C. Nusslein-Volhard.
Source for merge of: mbm CG11604
l(2)21Ca null alleles complement the lethality of Plc21C nulls and complement alleles of mbm (contra FBrf0075905 and FBrf0064301).