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FB2024_02
,
released April 23, 2024
ref(3)D, Dro18-2
Please see the JBrowse view of Dmel\CHKov1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Mutation in sequenced strain: insertion of transposon; an insertion allele segregating in wild-type strains; see CHKov1[Doc1420].
The Doc transposable element insertion is correlated with pesticide resistance (FBrf0188316) and resistance to sigma virus (FBrf0216506); may be due to effect upon CHKov2 (FBrf0216506), rather than a function of atypical CHKov1 transcripts.
Atypical transcripts containing Doc sequences have been described (FBrf0188316) and were included in the FlyBase gene model annotation prior to release 5.53.
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CHKov1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\CHKov1 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG10618 BcDNA:GH03753
l(3)rJ880 may correspond to CHKov1: the P{PZ}l(3)rJ880rJ880 insertion maps within the transcription unit.
Insertion of a Doc element into CHKov1 (Doc{}CHKov1Doc1420) increases resistance to Sigma virus compared to control flies lacking the insertion. The rearranged Dp(3;3)CHKov chromosome, which is derived from the Doc{}CHKov1Doc1420 chromosome, shows a further increase in resistance to Sigma virus compared to the Doc{}CHKov1Doc1420 progenitor. Since the rearrangement amplifies the region coding for CHKov1 containing the Doc insertion, the simplest explanation for the increased resistance to Sigma of the Dp(3;3)CHKov chromosome is that the amplification of the region coding for CHKov1 containing Doc increases the resistance. However, no evidence has been found for the expression of CHKov1 changing in Dp(3;3)CHKov relative to Doc{}CHKov1Doc1420, while the Dp(3;3)CHKov rearrangement is associated with a 6- to 9-fold increase in expression of the related CHKov2 gene. Thus it is possible that both CHKov1 and CHKov2 play a role in resistance to Sigma virus (and thus that the locus previously referred to as "ref(3)D" corresponds to CHKov1 and CHKov2).
Source for merge of CG10618 BcDNA:GH03753 was a shared cDNA (GH03753) ( date:011030 ).
Source for identity of: CHKov1 CG10618
