FB2024_02 , released April 23, 2024
Allele: Dmel\CHKov1Doc1420
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General Information
Symbol
Dmel\CHKov1Doc1420
Species
D. melanogaster
Name
FlyBase ID
FBal0190391
Feature type
allele
Associated gene
Dmel\CHKov1
Associated Insertion(s)
Doc{}CHKov1Doc1420
Carried in Construct
Also Known As
FBti0019430
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(González et al., 2008, Aminetzach et al., 2005)
Progenitor genotype
Associated Insertion(s)
Doc{}CHKov1Doc1420
Cytology
Description

Doc insertion in the second exon.

(Aminetzach et al., 2005)

Mutation in sequenced strain: insertion of Doc transposon. This insertion is segregating in wild-type strains (see FBrf0188316).

(FlyBase Curators, 2002-)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies homozygous for the Doc{}CHKov1Doc1420 insertion show increased resistance to Sigma virus compared to control flies lacking the insertion, with infection rates dropping from 82% to 30%.

      (Magwire et al., 2011)

      Flies carrying CHKov1Doc1420 have an increased resistance to organophosphates compared to controls.

      (Aminetzach et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CHKov1-doc1420
      (Magwire et al., 2011)
      CHKov1Doc1420
      Doc1420
      (ffrench-Constant et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)