FlyBase Gene Report: Dmel\HDAC4

General Information

Symbol

Dmel\HDAC4

Species

D. melanogaster

Name

Histone deacetylase 4

Annotation Symbol

CG1770

Feature Type

protein_coding_gene

FlyBase ID

FBgn0041210

Gene Model Status

Current

Stock Availability

21 publicly available

Enzyme Name (EC)

histone deacetylase (3.5.1.98)

Gene Summary

Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dHDAC4, HDAC4a, HDAC

Key Links

Genomic Location

Cytogenetic map

11E8-11E9

Sequence location

X:13,262,687..13,285,632 [-]

Recombination map

1-42

RefSeq locus

NC_004354 REGION:13262687..13285632

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables histone deacetylase activity

inferred from direct assay

(Cho et al., 2005)

inferred from mutant phenotype

(Feller et al., 2015)

enables protein lysine deacetylase activity

inferred from direct assay

(Wang et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables histone deacetylase activity

inferred from electronic annotation with InterPro:IPR046949

(InterPro Project Members, 2004-)

enables NAD-independent histone deacetylase activity

non-traceable author statement

(Feller et al., 2015)

enables SUMO transferase activity

inferred from sequence or structural similarity with UniProtKB:P56524

(Gene Ontology Curators, 2002-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in cellular response to starvation

inferred from expression pattern

(Choi et al., 2015)

involved_in insulin receptor signaling pathway

inferred from mutant phenotype

(Wang et al., 2011)

involved_in long-term memory

inferred from mutant phenotype

(Fitzsimons et al., 2013)

involved_in memory

inferred from mutant phenotype

(Fitzsimons et al., 2013)

involved_in positive regulation of DNA-templated transcription

inferred from mutant phenotype

(Wang et al., 2011)

involved_in regulation of DNA-templated transcription

inferred from direct assay

(Cho et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in negative regulation of transcription by RNA polymerase II

inferred from electronic annotation with InterPro:IPR046949

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Cho et al., 2005)

located_in cytosol

inferred from direct assay

(Choi et al., 2015, Cho et al., 2005)

located_in nucleus

inferred from direct assay

(Choi et al., 2015, Cho et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RPD3/HDA1 LYSINE DEACETYLASES

SUMO TRANSFERASES

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

histone deacetylase activity

H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone] (3.5.1.98)

RHEA 58196: protein lysine deacetylase activity
RHEA 58108:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RPD3/HDA1 LYSINE DEACETYLASES -: The RPD3/HDA1 family are Zn²⁺-dependent lysine deacetylases that share a common catalytic core domain. (Adapted from FBrf0159755).
SUMO TRANSFERASES -: SUMO transferases catalyze the transfer of SUMO from either E2 or E3 enzyme to a substrate.

Pathway (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\HDAC4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PHQ2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

HDAC4-RB

FBtr0073798

NM_167356

5182

1181

HDAC4-RD

FBtr0301298

NM_132640

6312

1252

HDAC4-RE

FBtr0301299

NM_001014736

5299

1203

HDAC4-RF

FBtr0308576

NM_001258722

5487

1242

HDAC4-RG

FBtr0333331

NM_001272578

6876

1269

HDAC4-RH

FBtr0333332

NM_001272579

6510

1181

HDAC4-RI

FBtr0333333

NM_001272580

6559

1205

HDAC4-RJ

FBtr0333334

NM_001272581

6248

1205

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

HDAC4-PB

FBpp0073629

126.0

1181

8.11

FBpp0290513

134.2

1252

7.79

FBpp0290514

128.6

1203

7.18

FBpp0300800

133.1

1242

7.79

FBpp0305523

136.2

1269

7.95

FBpp0305524

126.0

1181

8.11

FBpp0305525

129.0

1205

8.27

FBpp0305526

129.0

1205

8.27

M9PJM2

NP_001259510

AGB95352

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1181 aa isoforms: HDAC4-PB, HDAC4-PH

1205 aa isoforms: HDAC4-PI, HDAC4-PJ

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HDAC4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.12

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism | ubiquitous

• perinuclear region of cytoplasm

(Zeremski et al., 2003)

embryonic stage 4

organism | anterior

(Zeremski et al., 2003)

embryonic stage 5 -- 11

organism | segment polarity expression pattern

(Zeremski et al., 2003)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Zeremski et al., 2003)

Additional Descriptive Data

In early embryos (< 1 hour AEL) HDAC4 is expressed ubiquitously, and concentrated around the nuclei. At about 2 hours of development expression is decreased, and is refined to a broad anterior domain. Seven stripes appear at cellularization, between 70% and 24% egg length, the broad anterior stripe is lessened in intensity. During gastrulation, anoter seven stripes appear between the first seven, and these are maintainted through embryonic stage 11. The 3 kB transcript is predominant in larvae, while the 5.5 kB transcript is predominant in embryos and adults.

(Zeremski et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Kenyon cell

(Fitzsimons et al., 2013)

calyx of adult mushroom body

(Fitzsimons et al., 2013)

Additional Descriptive Data

A single confocal plane through the Kenyon cells

(Fitzsimons et al., 2013)

at the level of the calyx (asterisk) shows HDAC4 is predominantly localized to the calyx and cytoplasm. In a subset of cells, nuclear HDAC4 expression is observed, which always co-localizes with Mef2.

(Fitzsimons et al., 2013)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Cho et al., 2005)

located_in cytosol

inferred from direct assay

(Choi et al., 2015, Cho et al., 2005)

located_in nucleus

inferred from direct assay

(Choi et al., 2015, Cho et al., 2005)

Expression Deduced from Reporters

Reporter: P{Switch2}HDAC4^GSG3938

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval neuron | subset

(Nicholson et al., 2008)

chordotonal organ | intense

(Nicholson et al., 2008)

neuron | subset of larval ventral nerve cord | lateral | restricted | segmentally repeated

(Nicholson et al., 2008)

Reporter: PBac{602.P.SVS-1}HDAC4^CPTI000077

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult mushroom body | faint

(Fitzsimons et al., 2013)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\HDAC4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\HDAC4

View exonic expression by tissue for Dmel\HDAC4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32278/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041210

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041210

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041210

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1770

Flygut - An atlas of the Drosophila adult midgut

FBgn0041210

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of HDAC4

Transgenic constructs containing regulatory region of HDAC4

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

HDAC4^GD9446

viable, with Scer\GAL4^Mef2.PR

HDAC4^GD9446

viable, with Scer\GAL4^pnr-MD237

HDAC4^GD9446

viable, with Scer\GAL4^tin.CΔ4

HDAC4^GD9446

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

HDAC4^GD9446

abnormal eye color | adult stage, with Scer\GAL4^GMR.PF

abnormal memory, with Scer\GAL4¹⁴⁷¹, Scer\GAL80^ts.αTub84B

HDAC4^{UAS.hs.Tag:FLAG}

abnormal memory, with Scer\GAL4^ey-OK107, Scer\GAL80^ts.αTub84B

abnormal memory, with Scer\GAL4^Mef2.247, Scer\GAL80^ts.αTub84B

HDAC4^{UAS.hs.Tag:FLAG}

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

abnormal neuroanatomy | adult stage, with Scer\GAL4^ey-OK107

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^ey-OK107

increased cell number | adult stage, with Scer\GAL4^Tk.PS

HDAC4^HM05035

visible | adult stage, with Scer\GAL4^GMR.PF

Phenotype manifest in

Allele

adult anterior midgut, with Scer\GAL4^Tk.PS

HDAC4^HM05035

adult enteroendocrine cell | increased number, with Scer\GAL4^Tk.PS

HDAC4^HM05035

adult fat body, with Scer\GAL4^Tk.PS

HDAC4^HM05035

adult mushroom body, with Scer\GAL4^elav-C155

eye, with Scer\GAL4^GMR.PF

interommatidial bristle | adult stage, with Scer\GAL4^GMR.PF

lipid droplet | adult stage, with Scer\GAL4^Tk.PS

HDAC4^HM05035

lobe system of adult mushroom body, with Scer\GAL4^elav-C155

lobe system of adult mushroom body, with Scer\GAL4^ey-OK107

medial lobe of adult mushroom body, with Scer\GAL4^elav-C155

HDAC4^UAS.Tag:MYC

medial lobe of adult mushroom body, with Scer\GAL4^ey-OK107

mesothoracic tergum, with Scer\GAL4^pnr-MD237

HDAC4^GD9446

ommatidium | adult stage, with Scer\GAL4^GMR.PF

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (11)

Hsap\HDAC9

13 of 14

Yes

Hsap\HDAC4

12 of 14

Yes

Hsap\HDAC5

12 of 14

Yes

Hsap\HDAC7

10 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Hdac9

13 of 14

Yes

Rnor\Hdac4

12 of 14

Yes

Rnor\Hdac5

12 of 14

Yes

Rnor\Hdac7

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Hdac5

12 of 14

Yes

Mmus\Hdac4

11 of 14

Yes

Mmus\Hdac7

10 of 14

Yes

Mmus\Hdac9

7 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\hdac4

7 of 13

Yes

Xtro\hdac5

6 of 13

Yes

Xtro\hdac7

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\hdac10

1 of 13

Xtro\ina

1 of 13

Yes

Xtro\slc4a4

1 of 13

Danio rerio (Zebrafish) (12)

Drer\hdac5

12 of 14

Yes

Drer\hdac4

11 of 14

Yes

Drer\hdac7a

7 of 14

Yes

Drer\hdac7b

5 of 14

Yes

Drer\hdac6

4 of 14

Drer\hdac9b

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\hda-4

10 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP000410

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\HDA05

5 of 13

Yes

Atha\HDA14

5 of 13

Yes

Atha\HDA15

5 of 13

Yes

Atha\HDA08

4 of 13

Yes

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\hda17

2 of 13

Yes

Atha\AT4G09784

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\HDA1

4 of 13

Yes

Scer\HOS3

3 of 13

Yes

Scer\HOS1

2 of 13

Scer\HOS2

2 of 13

Scer\RPD3

2 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\clr3

5 of 12

Yes

Spom\clr6

2 of 12

Spom\hos2

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:HDAC4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

6 of 13

4 of 13

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

HDAC4^KG09091

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

HDAC4^HMS00083

ameliorates epilepsy

modeled by Sh¹²⁰, eag¹

(Li et al., 2021)

HDAC4^HM05035

ameliorates epilepsy

modeled by Sh¹²⁰, eag¹

(Li et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HDAC9; histone deacetylase 9

13 of 14

606543

AURICULOCONDYLAR SYNDROME 4; ARCND4

HDAC4; histone deacetylase 4

12 of 14

605314

NEURODEVELOPMENTAL DISORDER WITH CENTRAL HYPOTONIA AND DYSMORPHIC FACIES; NEDCHF

HDAC5; histone deacetylase 5

12 of 14

605315

HDAC7; histone deacetylase 7

10 of 14

606542

HDAC6; histone deacetylase 6

4 of 14

300272

CHONDRODYSPLASIA WITH PLATYSPONDYLY, DISTINCTIVE BRACHYDACTYLY, HYDROCEPHALY, AND MICROPHTHALMIA

chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia

HDAC10; histone deacetylase 10

3 of 14

608544

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

HDAC4 - Kdm5

anti bait coimmunoprecipitation, western blot

(Liu et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

HDAC4

suppressible

Mef2

(Main et al., 2021)

HDAC4

enhanceable

Mef2

(Tan et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58662

DroID - A comprehensive database of gene and protein interactions.

FBgn0041210

MIST (protein-protein) - An integrated Molecular Interaction Database

32278

Pathways

Signaling Pathways (FlyBase)

Insulin-like Receptor Signaling Pathway Core Components -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-42

Cytogenetic map

11E8-11E9

Sequence location

X:13,262,687..13,285,632 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11E8-11E9

Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640^EP1626

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

11F-12A

(Mallin et al., 2000)

Experimentally Determined Recombination Data

Location

1-42

(FlyBase, 2016)

1-42.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

601107

w¹¹¹⁸; P{VT061192-p65.AD}attP40

75098

w¹¹¹⁸; P{VT061192-GAL4.DBD}attP2

40253

w^* P{Switch2}HDAC4^GSG3938

28549

y¹ v¹; P{TRiP.HM05035}attP2

41420

y¹ w^* Mi{MIC}HDAC4^MI05513

50817

y¹ w^* P{PTT-GA}HDAC4^CA07134

Korea

13037

P{VT061192-GAL4}attP2

11136

P{EP}HDAC4^G9667

Kyoto

124132

w¹¹¹⁸ P{RS3}HDAC4^CB-6512-3

125745

w¹¹¹⁸ P{RS5}HDAC4^5-HA-2919

VDRC

v330055

P{VSH330055}attP40

v20522

w¹¹¹⁸; P{GD9446}v20522

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (32)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0041210

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0041210

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

HDAC4 is a repressor of long-term memory and modulates normal memory formation.

(Fitzsimons et al., 2013)

S2 cells which have been treated with dsRNA made from templates generated with primers directed against HDAC4 show no significant inhibition of cell growth.

(Foglietti et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: HDAC4 CG1770

(Bornemann, 2000.10.26)

Source for merge of: HDAC4 HDAC4a

(FlyBase, 1996-)

Additional comments

Source for merge of HDAC4 HDAC4a was sequence comparison ( date:030604 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG1770

(Meadows, 2017.1.11, Ni et al., 2011.7.19, Krejcí et al., 2009, Perkins et al., 2009, Foglietti et al., 2006, Barlow et al., 2001, Bornemann, 2000.10.26, Courey, 2000.6.28)

DHDAC4

(Foglietti et al., 2006, Miotto et al., 2006)

GC1770

(Moazed, 2001)

HDAC

(Padmanabhan et al., 2006, Guenther and Lazar, 2001)

HDAC4

(Kurhaluk, 2024, Loreto et al., 2024, Bhatnagar et al., 2023, Lones and DiAntonio, 2023, Schwartz et al., 2023, Titlow et al., 2023, Wippich et al., 2023, Cho et al., 2022, Miao et al., 2022, Ahmad et al., 2021, Chatterjee and Perrimon, 2021, Keegan and Hughes, 2021, Liang et al., 2021, Main et al., 2021, Parra-Peralbo et al., 2021, Raun et al., 2021, Yamaguchi et al., 2021, Toprak et al., 2020, Adusumalli et al., 2019, Sang Cho et al., 2019, Shimaji et al., 2019, Su et al., 2019, Gene Disruption Project members, 2018-, Lehmann, 2018, Musselman and Kühnlein, 2018, Wu et al., 2018, Fujii et al., 2017, Perry et al., 2017, Transgenic RNAi Project members, 2017-, Schwartz et al., 2016, Choi et al., 2015, Nikalayevich and Ohkura, 2015, Ashwal-Fluss et al., 2014, Ho et al., 2014, Liu et al., 2014, Fitzsimons et al., 2013, Ronen et al., 2013, Sen et al., 2013, Cole et al., 2012.7.6, Hainaut et al., 2012, Milon et al., 2012, Pushpavalli et al., 2012, Nègre et al., 2011, Wang et al., 2011, Zhou et al., 2011, Gan et al., 2010, Dworkin et al., 2009, Krejcí et al., 2009, Cao et al., 2008, Pallos et al., 2008, Buszczak et al., 2007, Cho et al., 2005)

HDAC4a

(Boyle et al., 2014, Slattery et al., 2014)

Hdac4

(Heier et al., 2021)

dHDAC4

(Taylor-Harding et al., 2004, Zeremski et al., 2003, Barlow et al., 2001, Bornemann, 2000.10.26, Mallin et al., 2000)

dmHDA405

(Pandey et al., 2002)

hdac4

(Larschan et al., 2012)

Name Synonyms

HDAC4

Histone Deacetylase 4

(Fitzsimons et al., 2013)

Histone deacetylase 4

Secondary FlyBase IDs

FBgn0030464
FBgn0063926

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_regulation_chromatin

genome binding

Genome-wide localization of chromatin factors by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 107 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32278

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PHQ2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PHQ2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32278/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041210

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041210

FlyMine - An integrated database for Drosophila genomics

FBgn0041210

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1770

MARRVEL_MODEL - MARRVEL (model organism gene)

32278

Linkouts

BioGRID - A database of protein and genetic interactions.

58662

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0041210

DroID - A comprehensive database of gene and protein interactions.

FBgn0041210

DRSC - Results frm RNAi screens

FBgn0041210

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041210

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0041210

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1770

Flygut - An atlas of the Drosophila adult midgut

FBgn0041210

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0041210

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014342

MIST (protein-protein) - An integrated Molecular Interaction Database

32278

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (118)

The following external sites may use different assemblies or annotations than FlyBase.

-1.12

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