dRrp6
Please see the JBrowse view of Dmel\Rrp6 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Gene model reviewed during 5.56
Low-frequency RNA-Seq exon junction(s) not annotated.
Interacts with spn-A/Rad51; the interaction is required for the recruitment of spn-A to the DNA-damage response foci (PubMed:25632158). Interacts with Su(var)3-9, a heterochromatin factor; the interaction promotes association of Rrp6 with a subset of genomic loci (PubMed:26389589). Interacts with Su(var)205, a heterochromatin factor (PubMed:26389589). Interacts with HDAC1, a heterochromatin factor (PubMed:26389589).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rrp6 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Rrp6 in JBrowse3-56
3-54.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : Inducible stable S2 cell lines were established that express full length Tag:V5-tagged Rrp4, Rrp6, or Ski6.
New stable cell line derived from S2-unspecified : Stable S2 cell lines were created expressing copper-inducible epitope-tagged exosome subunits to examine the subcellular distribution of exosome complex components. Stable lines were created containing the following exosome subunits; Dis3, Rrp6, Mtr3, Rrp42, Rrp4, Ski6, Rrp46, Rrp40, and Csl4.
Identification: as a protein that copurifies with Spt6 protein.
Source for identity of: Rrp6 CG7292
