FB2024_04 , released June 25, 2024
Gene: Dmel\HtrA2
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General Information
Symbol
Dmel\HtrA2
Species
D. melanogaster
Name
HTRA2-related serine protease
Annotation Symbol
CG8464
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038233
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1. (UniProt, Q9VFJ3)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

omi, dOmi, DmHtrA2

Key Links
Genomic Location
Cytogenetic map
88C3-88C3
Sequence location
Recombination map
3-55
RefSeq locus
NT_033777 REGION:14509049..14511712
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables peptidase activity
inferred from direct assay
(Tain et al., 2009, Khan et al., 2008)
enables protein binding
inferred from physical interaction with FLYBASE:rho-7; FB:FBgn0033672
(Whitworth et al., 2008)
inferred from physical interaction with UniProtKB:Q24306
(Khan et al., 2008, Igaki et al., 2007)
enables serine hydrolase activity
inferred from high throughput direct assay
(Kumar et al., 2021)
enables serine-type endopeptidase activity
inferred from direct assay
(Challa et al., 2007)
inferred from mutant phenotype
(Khan et al., 2008, Igaki et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables serine-type endopeptidase activity
inferred from electronic annotation with InterPro:IPR001940
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000533466
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in ectopic germ cell programmed cell death
inferred from mutant phenotype
(Yacobi-Sharon et al., 2013)
involved_in mitochondrion organization
inferred from mutant phenotype
(Tain et al., 2009)
involved_in positive regulation of apoptotic process
inferred from direct assay
(Challa et al., 2007)
inferred from mutant phenotype
(Challa et al., 2007)
involved_in regulation of apoptotic process
inferred from mutant phenotype
(Khan et al., 2008, Challa et al., 2007, Igaki et al., 2007)
involved_in spermatogenesis
inferred from mutant phenotype
(Yun et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in positive regulation of apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN001117853
(GO Reference Genome Project, 2011-)
involved_in programmed cell death
inferred from biological aspect of ancestor with PANTHER:PTN001117853
(GO Reference Genome Project, 2011-)
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001940
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000533466
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrial intermembrane space
inferred from direct assay
(Khan et al., 2008, Igaki et al., 2007)
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrion
inferred from direct assay
(Khan et al., 2008, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Yun et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase S1C family. (Q9VFJ3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RHG PROTEINS -
RHG proteins possess a 12 amino acid RHG motif. This motif, also known as the IAP-binding motif (IBM), interacts with the BIR domain of Inhibitor of apoptosis proteins (IAPs) and relieving IAP-mediated caspase inhibition. Over-expression of individual RHG proteins is sufficient to induce apoptosis. (Adapted from FBrf0225510).
S1C SERINE PEPTIDASES -
S1C serine peptidases belong to MEROPS family S1, subfamily C. It is a relatively small family in Drosophila melanogaster. (Adapted from FBrf0239469.)
Protein Function (UniProtKB)
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1.
(UniProt, Q9VFJ3)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\HtrA2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VFJ3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
HtrA2-RA
FBtr0082987
NM_142109
1415
422
HtrA2-RB
FBtr0330045
NM_001275636
2512
422
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
HtrA2-PA
FBpp0082446
46.0
422
10.00
Q9VFJ3
NP_650366
AAF55062
HtrA2-PB
FBpp0303078
46.0
422
10.00
Q9VFJ3
NP_001262565
AGB95946
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

422 aa isoforms: HtrA2-PA, HtrA2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with th/DIAP1 (via BIR 2 domain) (PubMed:18259196). Interacts with Pink1 and rho-7 (PubMed:19048081).

(UniProt, Q9VFJ3)
Post Translational Modification

Ubiquitinated by th, thereby antagonizing induced cell death.

Autoproteolytically cleaved into active forms in the mitochondria.

(UniProt, Q9VFJ3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HtrA2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.19

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrial intermembrane space
inferred from direct assay
(Khan et al., 2008, Igaki et al., 2007)
inferred from direct assay
(Challa et al., 2007)
located_in mitochondrion
inferred from direct assay
(Khan et al., 2008, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Yun et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\HtrA2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of HtrA2
Transgenic constructs containing regulatory region of HtrA2
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene partially disrupted in
Df(3R)HtrA2Δ1
(Tain et al., 2009)
Gene disrupted in
Df(3R)HtrA2Df1
(Yacobi-Sharon et al., 2013)
Df(3R)HtrA2Df2
(Yacobi-Sharon et al., 2013)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4da.G32
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4Tub.PU
viable (with Df(3R)ED5644)
Sterility
Allele
female fertile
fertile, with Scer\GAL4da.G32
male fertile
male sterile
male sterile (with Df(3R)ED5644)
male sterile (with HtrA2NSO)
male sterile (with HtrA2V110E)
Other Phenotypes
Allele
abnormal locomotor behavior
chemical resistant | adult stage, with Scer\GAL4da.G32
chemical sensitive
decreased cell death (with Df(3R)HtrA2Df1)
decreased cell death (with Df(3R)HtrA2Df2)
decreased cell death | dominant
flightless
radiation resistant | third instar larval stage, with Scer\GAL4da.G32
short lived
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible
visible, with Scer\GAL4GMR.PF
visible | heat sensitive
visible | heat sensitive, with Scer\GAL4GMR.PF
visible | pupal stage, with Scer\GAL4da.G32
Phenotype manifest in
Allele
eye
eye, with Scer\GAL4GMR.PF
eye | heat sensitive
eye | heat sensitive, with Scer\GAL4GMR.PF
eye | pupal stage, with Scer\GAL4da.G32
indirect flight muscle cell, with Scer\GAL4Mef2.PR
investment cone (with Df(3R)ED5644)
male germline cell
male germline cell (with Df(3R)HtrA2Df1)
male germline cell (with Df(3R)HtrA2Df2)
mitochondrion & indirect flight muscle
spermatid cyst (with Df(3R)ED5644)
spermatogonial cyst
spermatozoon
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\HTRA2
12 of 14
Yes
Yes
1  
Hsap\HTRA1
10 of 14
No
Yes
Hsap\HTRA3
10 of 14
No
Yes
Hsap\HTRA4
8 of 14
No
Yes
Hsap\TYSND1
2 of 14
No
No
1  
Hsap\LIMK2
1 of 14
No
No
Hsap\PSMD9
1 of 14
No
No
1  
Hsap\USH1C
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Htra2
12 of 14
Yes
Yes
Rnor\Htra1
9 of 14
No
Yes
Rnor\Htra3
9 of 14
No
Yes
Rnor\Htra4
8 of 14
No
Yes
Rnor\Cytip
1 of 14
No
No
Rnor\Limk2
1 of 14
No
No
Rnor\Pdzd7
1 of 14
No
No
Rnor\Psmd9
1 of 14
No
No
Rnor\Snx27
1 of 14
No
No
Rnor\Tysnd1
1 of 14
No
No
Rnor\Ush1c
1 of 14
No
No
Mus musculus (laboratory mouse) (11)
Mmus\Htra2
12 of 14
Yes
Yes
Mmus\Htra1
9 of 14
No
Yes
Mmus\Htra4
9 of 14
No
Yes
Mmus\Htra3
8 of 14
No
Yes
Mmus\Cytip
1 of 14
No
No
Mmus\Limk2
1 of 14
No
No
Mmus\Pdzd7
1 of 14
No
No
Mmus\Psmd9
1 of 14
No
No
Mmus\Snx27
1 of 14
No
No
Mmus\Tysnd1
1 of 14
No
No
Mmus\Ush1c
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\htra3
8 of 13
Yes
Yes
Xtro\htra4
8 of 13
Yes
Yes
Xtro\htra1
7 of 13
No
Yes
Xtro\htra2
6 of 13
No
Yes
Xtro\LOC100496042
1 of 13
No
Yes
Danio rerio (Zebrafish) (53)
Drer\htra3a
11 of 14
Yes
Yes
Drer\si:dkey-33c12.12
11 of 14
Yes
Yes
Drer\si:dkey-112g5.16
11 of 14
Yes
Yes
Drer\htra1a
10 of 14
No
Yes
Drer\htra1b
10 of 14
No
Yes
Drer\htra4
10 of 14
No
Yes
Drer\LOC560917
10 of 14
No
Yes
Drer\LOC110438948
9 of 14
No
Yes
Drer\htra3b
8 of 14
No
Yes
Drer\LOC110438965
8 of 14
No
Yes
Drer\si:dkey-10b15.8
7 of 14
No
Yes
Drer\si:dkey-84o3.7
7 of 14
No
Yes
Drer\si:dkey-112g5.13
7 of 14
No
Yes
Drer\zgc:174193
7 of 14
No
Yes
Drer\si:dkey-33c12.10
6 of 14
No
Yes
Drer\si:dkey-84o3.2
6 of 14
No
Yes
Drer\LOC797799
5 of 14
No
Yes
Drer\LOC799006
5 of 14
No
Yes
Drer\LOC100331049
5 of 14
No
Yes
Drer\LOC103909414
5 of 14
No
Yes
Drer\si:busm1-sl7.7
5 of 14
No
Yes
Drer\si:dkey-19p15.4
5 of 14
No
Yes
Drer\LOC100331451
4 of 14
No
Yes
Drer\LOC101883763
4 of 14
No
Yes
Drer\si:dkey-33c12.11
4 of 14
No
Yes
Drer\si:dkey-33c12.13
4 of 14
No
Yes
Drer\LOC100149285
3 of 14
No
Yes
Drer\LOC100149563
3 of 14
No
Yes
Drer\LOC110437759
3 of 14
No
Yes
Drer\LOC110437853
3 of 14
No
Yes
Drer\LOC110437868
3 of 14
No
Yes
Drer\LOC793110
2 of 14
No
Yes
Drer\LOC793521
2 of 14
No
Yes
Drer\grid2ipa
1 of 14
No
No
Drer\LOC562245
1 of 14
No
Yes
Drer\LOC799834
1 of 14
No
Yes
Drer\LOC100330882
1 of 14
No
Yes
Drer\LOC100333082
1 of 14
No
Yes
Drer\LOC100535800
1 of 14
No
Yes
Drer\LOC103911769
1 of 14
No
Yes
Drer\LOC108179121
1 of 14
No
Yes
Drer\LOC110437735
1 of 14
No
Yes
Drer\LOC110437830
1 of 14
No
Yes
Drer\LOC110437862
1 of 14
No
Yes
Drer\LOC110438860
1 of 14
No
Yes
Drer\LOC110438863
1 of 14
No
Yes
Drer\LOC110438864
1 of 14
No
Yes
Drer\LOC110438950
1 of 14
No
Yes
Drer\LOC110438955
1 of 14
No
Yes
Drer\LOC110438956
1 of 14
No
Yes
Drer\pdzd3b
1 of 14
No
No
Drer\psmd9
1 of 14
No
No
Drer\scrib
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\lim-8
1 of 14
Yes
No
Cele\psmd-9
1 of 14
Yes
No
Cele\txbp-3
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP000240
12 of 12
Yes
Yes
Agam\AgaP_AGAP000054
1 of 12
No
No
Agam\AgaP_AGAP000201
1 of 12
No
No
Agam\AgaP_AGAP005054
1 of 12
No
No
Agam\AgaP_AGAP008321
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (19)
Atha\DEG14
11 of 13
Yes
Yes
Atha\DEG1
6 of 13
No
Yes
Atha\DEG8
6 of 13
No
Yes
Atha\DEG5
4 of 13
No
Yes
Atha\DEG2
2 of 13
No
Yes
Atha\DEG3
2 of 13
No
Yes
Atha\DEG4
2 of 13
No
Yes
Atha\DEG6
2 of 13
No
Yes
Atha\DEG7
2 of 13
No
Yes
Atha\DEG9
2 of 13
No
Yes
Atha\DEG10
2 of 13
No
Yes
Atha\DEG11
2 of 13
No
Yes
Atha\DEG12
2 of 13
No
Yes
Atha\DEG13
2 of 13
No
Yes
Atha\DEG15
2 of 13
No
No
Atha\DEG16
2 of 13
No
Yes
Atha\AT1G54700
1 of 13
No
Yes
Atha\AT3G03370
1 of 13
No
Yes
Atha\AT5G57950
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\NMA111
4 of 13
Yes
Yes
Scer\NAS2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPAC23G3.12c
2 of 12
Yes
Yes
Spom\SPAC2H10.02c
1 of 12
No
No
Spom\SPBC1685.05
1 of 12
No
Yes
Escherichia coli (enterobacterium) (3)
Ecol\degP
8 of 11
Yes
Yes
Ecol\degQ
8 of 11
Yes
Yes
Ecol\degS
8 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:HtrA2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG3589
2 of 13
CG9588
1 of 13
Dlg5
1 of 13
dysc
1 of 13
scrib
1 of 13
Zasp52
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
HtrA2ΔPDZ.GMR
model of  Parkinson's disease
CEA
(Khan et al., 2008)
HtrA2Δ1
model of  Parkinson's disease
CEA
(Tain et al., 2009)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 5 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HTRA2; HtrA serine peptidase 2
12 of 14
606441
 
HTRA1; HtrA serine peptidase 1
10 of 14
602194
HTRA3; HtrA serine peptidase 3
10 of 14
608785
      HTRA4; HtrA serine peptidase 4
      8 of 14
      610700
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          esyN Network Diagram
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          esyN Network Key:
          Suppression
          Enhancement
          Other Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          HtrA2
          suppressible
          Diap1
          (Khan et al., 2008)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          park
          enhanceable
          HtrA2
          (Tain et al., 2009)
          park|Pink1
          suppressible
          HtrA2
          (Whitworth et al., 2008)
          Pink1
          enhanceable
          HtrA2
          (Whitworth et al., 2008, Yun et al., 2008)
          Pink1
          suppressible
          HtrA2
          (Tain et al., 2009, Whitworth et al., 2008)
          rho-7
          suppressible
          HtrA2
          (Whitworth et al., 2008)
          rho-7
          enhanceable
          HtrA2
          (Whitworth et al., 2008)
          YME1L
          suppressible
          HtrA2
          (Qi et al., 2016)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with th/DIAP1 (via BIR 2 domain) (PubMed:18259196). Interacts with Pink1 and rho-7 (PubMed:19048081).
          (UniProt, Q9VFJ3 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-55
          Cytogenetic map
          88C3-88C3
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          88C3-88C3
          Limits computationally determined from genome sequence between P{PZ}cv-c06951 and P{PZ}put10460
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-55

          (FlyBase, 2016)

          3-54.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (8)
          Genomic Clones (16)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (1)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Khan et al., 2008, Igaki et al., 2007)
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)
                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: HtrA2 CG8464

                    (Igaki et al., 2003.6.16)
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (16)
                    Reported As
                    Symbol Synonym
                    CG8464
                    (Ceder and Fredriksson, 2022, Ibaraki et al., 2021, Jiang, 2019.3.1, Banerjee and Chinthapalli, 2014, Ni et al., 2010.12.1, Perkins et al., 2009, Tain et al., 2009, Khan et al., 2008, Shah et al., 2008, Yun et al., 2008, Challa et al., 2007, Tomancak et al., 2007, Giot et al., 2003)
                    DmHtrA2
                    (Igaki et al., 2007, Igaki et al., 2003.6.16)
                    Dmel_CG8464
                    (Rawlings and Barrett, 1996-)
                    HTRA2
                    (Ham et al., 2021)
                    HtrA2
                    (Mele et al., 2023, Ibaraki et al., 2021, Kumar et al., 2021, Naz and Siddique, 2021, Bolus et al., 2020, Chen et al., 2020, Aryal and Lee, 2019, Yadav and Srikrishna, 2019, Gene Disruption Project members, 2018-, Kutscher and Shaham, 2017, M'Angale and Staveley, 2017, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Spinazzi and De Strooper, 2016, Vanhauwaert and Verstreken, 2015, Steller et al., 2014.7.9, Yacobi-Sharon and Arama, 2014.4.14, Yacobi-Sharon et al., 2013, Holland et al., 2011, Muñoz-Soriano and Paricio, 2011, Tain et al., 2009, Xu et al., 2009, Khan et al., 2008, Whitworth et al., 2008, Yun et al., 2008, Park et al., 2006)
                    HtrA2/Omi
                    (Biskup and Moore, 2006)
                    Omi
                    (Buhlman et al., 2021, Jagannathan et al., 2018, Kutscher and Shaham, 2017, Spinazzi and De Strooper, 2016, Muñoz-Soriano and Paricio, 2011, Whitworth et al., 2008, Yun et al., 2008)
                    Omi/HtrA2
                    (Guo, 2012)
                    dOmi
                    (Chung et al., 2020, Qi et al., 2016, Abdelwahid et al., 2011, Xu et al., 2009, Khan et al., 2008, Challa et al., 2007)
                    domi
                    (Challa et al., 2007, Park et al., 2006)
                    htrA2
                    (Chan and McQuibban, 2013, Yacobi-Sharon et al., 2013, Whitworth et al., 2008)
                    htrA2/omi
                    (Yacobi-Sharon et al., 2013)
                    omi
                    (Joy et al., 2021, Napoletano et al., 2017, Chan and McQuibban, 2013, Yacobi-Sharon et al., 2013, Whitworth et al., 2008, Yun et al., 2008, Park et al., 2006)
                    Name Synonyms
                    HTRA2-related serine protease
                    (Steller et al., 2014.7.9)
                    HtrA2
                    Serine protease HTRA2
                    (Banerjee and Chinthapalli, 2014)
                    high temperature requirement A2
                    (Chan and McQuibban, 2013)
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 45 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (82)