Please see the JBrowse view of Dmel\Ae2 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Gene model reviewed during 5.45
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ae2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: enriched in acidic region
RNA-seq data show that Ae2 is expressed throughout the larval midgut but is enriched in the acidic region of the larval midgut.
Ae2 staining is seen in four distinct domains within the larval midgut. These are the copper cell region, a cell cluster anterior to the copper cells, the large flat cells and a more posterior cluster of 2-3 cells that may correspond to iron cells. The staining in the copper cell region localizes to the interstitial cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ae2 in JBrowse3-31
3-24.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG8177 anon- EST:Posey259
Source for merge of: CG8177 BcDNA:RE59468
Source for merge of CG8177 BcDNA:RE59468 was a shared cDNA ( date:030728 ).
Source for identity of: Ae2 CG8177
Named "Anion exchanger 2" based on the closest homolog in mouse and human genomes.
