FB2024_04 , released June 25, 2024
Gene: Dmel\DptB
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General Information
Symbol
Dmel\DptB
Species
D. melanogaster
Name
Diptericin B
Annotation Symbol
CG10794
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034407
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Diptericin, Dpt, DiptB, diptericin-like protein, Dipt

Key Links
Genomic Location
Cytogenetic map
55F8-55F8
Sequence location
Recombination map
2-86
RefSeq locus
NT_033778 REGION:18867391..18867895
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in defense response to Gram-positive bacterium
inferred from expression pattern
(Gordon et al., 2008)
involved_in humoral immune response
inferred from expression pattern
(Verleyen et al., 2006)
involved_in response to wounding
inferred from expression pattern
(Tattikota et al., 2020)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in defense response to bacterium
inferred from electronic annotation with InterPro:IPR005521
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from electronic annotation with InterPro:IPR005521
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED ANTIMICROBIAL PEPTIDES -
This group comprises antimicrobial peptides that are single gene family members in D. melanogaster. (Adapted from FBrf0241672.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\DptB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1ZBF6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
DptB-RA
FBtr0086621
NM_079063
449
120
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
DptB-PA
FBpp0085803
13.1
120
9.48
A1ZBF6
NP_523787
AAF57618
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DptB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.44

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval hemolymph

Comment: infected with M. luteus and E. coli

peptides: EIVNLQPEPLAYAPNFDVPLHRV

(Liu et al., 2006, Verleyen et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Liu et al., 2006, Verleyen et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\DptB in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of DptB
Transgenic constructs containing regulatory region of DptB
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)Dpt-SK1
(Hanson et al., 2019)
Df(2R)Exel6067
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\ATT
1 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:DptB. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
DptA
3 of 13
AttA
1 of 13
AttB
1 of 13
CG33493
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-86
    Cytogenetic map
    55F8-55F8
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55F8-55F8
    Limits computationally determined from genome sequence between P{PZ}l(2)0370903709 and P{lacW}prodk08810
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55F-55F
    (Borge, 2000.11.20)
    Experimentally Determined Recombination Data
    Location

    2-86

    (FlyBase, 2016)

    2-92.2

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (20)
    cDNA Clones (51)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
        Other Comments
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: DptB BcDNA:RH29451

        (FlyBase, 1996-)
        Additional comments

        Source for identity of DptB CG10794 was sequence comparison ( date:010102 ).

        (FlyBase, 1996-)

        Source for merge of DptB BcDNA:RH29451 was a shared cDNA ( date:030728 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of

        Source for identity of: DptB CG10794

        (FlyBase, 1996-)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (20)
        Reported As
        Symbol Synonym
        147473_at
        (Kristensen et al., 2005)
        BcDNA:RH29451
        CG10794
        (Sun et al., 2014, Petersen et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Hernandez-Romano et al., 2008, Valanne et al., 2007, Liu et al., 2006, Verleyen et al., 2006, De Gregorio et al., 2001, Hultmark, 2001.1.10, Irving et al., 2001, Lee et al., 2001, Lemaitre, 2000.12.20)
        Dipt
        (De Groef et al., 2021, Min and Tatar, 2018)
        DiptB
        (Liu and Jin, 2017, Vasudevan et al., 2017, Katzenberger et al., 2016, Cao et al., 2013, Katzenberger et al., 2013, Petersen et al., 2013, Petersen et al., 2012, Sampson et al., 2012, Ye and McGraw, 2011, Gordon et al., 2008)
        Diptericin
        (Madi et al., 2021, Bonnay et al., 2014, Kimbrell and Beutler, 2001)
        Diptericin B
        (Sciambra and Chtarbanova, 2021, Zhan et al., 2015, Felix et al., 2012)
        Dpt
        (Chen et al., 2022, Shrivastava et al., 2022, Ramond et al., 2021, Watson et al., 2021, Lin et al., 2020, Nonaka et al., 2020, Zhang et al., 2020, Kopp and Park, 2019, Liao et al., 2019, Troha et al., 2018, Daisley et al., 2017, Dostálová et al., 2017, Costechareyre et al., 2016, Guillou et al., 2016, Piegholdt et al., 2016, Merkling et al., 2015)
        DptB
        (Hersperger et al., 2024, Liang et al., 2024, Owings and Chow, 2024, Vesala et al., 2024, Bossen et al., 2023, Chen et al., 2023, Hsieh and Chiang, 2023, Huang et al., 2023, Kuyateh and Obbard, 2023, Lee et al., 2023, Lyman et al., 2023, Stączek et al., 2023, Tan et al., 2023, Deshpande et al., 2022, Kim et al., 2022, Liu et al., 2022, Shit et al., 2022, Takeuchi et al., 2022, Vaibhvi et al., 2022, Waring et al., 2022, Wu et al., 2022, Yoo et al., 2022, Hall et al., 2021, Kong et al., 2021, Yamashita et al., 2021, Benoit et al., 2020, Han et al., 2020, Hanson and Lemaitre, 2020, Newell et al., 2020, Sanuki, 2020, Seong et al., 2020, Shah et al., 2020, Swanson et al., 2020, Swanson et al., 2020, Yurkevych et al., 2020, Asri et al., 2019, Baenas and Wagner, 2019, Hanson et al., 2019, Houtz et al., 2019, Lin et al., 2019, Maitra et al., 2019, Moskalev et al., 2019, Sanuki et al., 2019, Štětina et al., 2019, Troha and Buchon, 2019, Barajas-Azpeleta et al., 2018, Gene Disruption Project members, 2018-, Grobler et al., 2018, Hemphill et al., 2018, Lin et al., 2018, Moskalev et al., 2018, Ueda et al., 2018, Yuan et al., 2018, Bozler et al., 2017, Christesen et al., 2017, Early et al., 2017, Mussabekova et al., 2017, Barekat et al., 2016, Kiss et al., 2016, Buchon and Osman, 2015, Hamilton et al., 2015, Kopp et al., 2015, Bonnay et al., 2014, Chen et al., 2014, Guo et al., 2014, Kuuluvainen et al., 2014, Taylor et al., 2014, Durdevic et al., 2013, Gendrin et al., 2013, Huang et al., 2013, Jennings, 2013, Shen et al., 2013, Short and Lazzaro, 2013, Stefanatos et al., 2013, Telonis-Scott et al., 2013, Doroszuk et al., 2012, Immonen and Ritchie, 2012, Kalajdzic et al., 2012, Vanha-Aho et al., 2012, Cheng et al., 2011, Gerbasi et al., 2011, Chen et al., 2010, Chen et al., 2010, Kim et al., 2010, Buchon et al., 2009, Feng et al., 2009, Sackton and Clark, 2009, Kleino et al., 2008, McGraw et al., 2008, Domanitskaya et al., 2007, Tsichritzis et al., 2007, Behm-Ansmant et al., 2006, King-Jones et al., 2006, Lazzaro et al., 2004, Domazet-Loso and Tautz, 2003)
        diptB
        (Hodge et al., 2022, Orme et al., 2016)
        dpt B
        (Zsindely et al., 2009)
        dptB
        (Zhang et al., 2020, Wei et al., 2018, Xu and Cherry, 2014, Huang et al., 2013, Kingsolver et al., 2013)
        dptlp
        (Cha et al., 2003, Lee et al., 2001)
        Name Synonyms
        Diptercin B
        (Xi et al., 2008)
        Diptericin
        (Eleftherianos and Tafesh-Edwards, 2022, Eleftherianos and Heryanto, 2021, Harnish et al., 2021, Marra et al., 2021, Ozakman and Eleftherianos, 2020, Younes et al., 2020, Merkling et al., 2019, Garschall and Flatt, 2018, Castillo et al., 2015, Merkling et al., 2015, Ferrandon, 2013, Vandersmissen et al., 2013, Moule et al., 2010, Lai et al., 2007, Tsichritzis et al., 2007, Kimbrell and Beutler, 2001)
        Diptericin B
        (Barati et al., 2022, Takeuchi et al., 2022, Gao et al., 2021, Schoberleitner et al., 2021, Lee et al., 2020, Ramond et al., 2020, Katzenberger et al., 2016, Unckless and Lazzaro, 2016, Arefin et al., 2014, Lee et al., 2014, Taylor et al., 2014, Longworth et al., 2012, Paré et al., 2012, Petersen et al., 2012, Cheng et al., 2011, Ragab et al., 2011, Wong et al., 2011, Kim et al., 2010, Ertürk-Hasdemir et al., 2009, Ye et al., 2009, Gordon et al., 2008, Hernandez-Romano et al., 2008, Kleino et al., 2008, Lazzaro et al., 2006, Verleyen et al., 2006, Lazzaro et al., 2004, Borge, 2000.11.20)
        Diptericin-B
        (Schneider and Imler, 2021, Bost et al., 2018, Bonnay et al., 2014, Kemp et al., 2013, Lemos et al., 2010)
        DiptericinB
        (Cao et al., 2013, Zhao et al., 2010)
        Diptericine
        (Espaillat et al., 2016)
        diptericin
        (Benoit et al., 2022, Kong et al., 2021, Lee et al., 2017)
        diptericin B
        (Chambers et al., 2012, Feng et al., 2009, Xi et al., 2008, Domanitskaya et al., 2007)
        diptericin-like protein
        (Cha et al., 2003, Lee et al., 2001)
        Secondary FlyBase IDs
        • FBgn0064827
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 38 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Flygut - An atlas of the Drosophila adult midgut
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        References (246)