BcDNA:GH08860 , l(2)k08903, jf5, tps, trehalose synthase
Please see the JBrowse view of Dmel\Tps1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tps1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Tps1 in JBrowse2-12
2-13.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The TPS (trehalose-6-phosphate synthase) and TPP (trehalose-6-phosphate phosphatase) domains of Tps1 are both required for trehalose synthesis in vivo.
Tps1 synthesises trehalose, predominantly in the fat body.
In vitro experiments showed that trehalose reduced protein aggregation caused by anoxia.
Upon induction of Tps1, trehalose increased and this was associated with increased tolerance to anoxia.
Homozygous Tps1 mutant leads to lethality at an early larval stage.
Overexpression of Tps1 results in increased tolerance to anoxia and an increase in trehalose levels.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.
Source for merge of: Tps1 l(2)24Ea
Source for merge of: l(2)k08903 BcDNA:GH08860
Source for identity of: tps1 BcDNA:GH08860