FlyBase Gene Report: Dmel\RecQ5

General Information

Symbol

Dmel\RecQ5

Species

D. melanogaster

Name

RecQ5 helicase

Annotation Symbol

CG4879

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027375

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

DNA 3'-5' helicase (5.6.2.4)

Gene Summary

RecQ5 helicase (RecQ5) encodes a DNA helicase that maintains genome stability via participation in many nuclear DNA metabolic processes including DNA repair, DNA resolution, and RNA transcription. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

RECQE, RECQ5/QE, DQ1, Q1

Key Links

Genomic Location

Cytogenetic map

70E5-70E5

Sequence location

3L:14,628,160..14,632,077 [-]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14628160..14632077

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from direct assay

(Kawasaki et al., 2002)

enables GTPase activity

inferred from direct assay

(Kawasaki et al., 2002)

enables single-stranded DNA helicase activity

inferred from direct assay

(Kawasaki et al., 2002, Ozsoy et al., 2001)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables 3'-5' DNA helicase activity

inferred from biological aspect of ancestor with PANTHER:PTN000344873

(GO Reference Genome Project, 2011-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR011545

(InterPro Project Members, 2004-)

enables DNA helicase activity

inferred from sequence or structural similarity with HGNC:9950

(Sekelsky et al., 2000)

enables four-way junction helicase activity

inferred from biological aspect of ancestor with PANTHER:PTN000344873

(GO Reference Genome Project, 2011-)

enables helicase activity

inferred from electronic annotation with InterPro:IPR004589

(InterPro Project Members, 2004-)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR011545

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in DNA damage response

inferred from direct assay

(Nakayama et al., 2009)

inferred from mutant phenotype

(Nakayama et al., 2006)

involved_in double-strand break repair via single-strand annealing

inferred from mutant phenotype

(Chen et al., 2010)

involved_in mitotic sister chromatid segregation

inferred from mutant phenotype

(Sakurai et al., 2011)

involved_in negative regulation of mitotic cell cycle

inferred from mutant phenotype

(Nakayama et al., 2006)

involved_in response to X-ray

inferred from direct assay

(Nakayama et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in DNA recombination

inferred from electronic annotation with InterPro:IPR004589

(InterPro Project Members, 2004-)

involved_in DNA unwinding involved in DNA replication

inferred from biological aspect of ancestor with PANTHER:PTN000344874

(GO Reference Genome Project, 2011-)

involved_in double-strand break repair via homologous recombination

inferred from biological aspect of ancestor with PANTHER:PTN000344874

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Sekelsky et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in chromosome

inferred from biological aspect of ancestor with PANTHER:PTN000344873

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000344873

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED GTPASES

RECQ-LIKE DNA HELICASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

3'-5' DNA helicase activity

Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction (5.6.2.4)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED GTPASES -: This group comprises GTPases that do not classify under other groups in FlyBase.
RECQ-LIKE DNA HELICASES -: The eukaryotic homologues of the Escherichia coli RecQ DNA helicase play conserved roles in the maintenance of genome stability, functioning during DNA replication and possibly in an S phase replication checkpoint. At least three of the human RecQ-like helicases are implicated in heritable diseases: BLM is mutated in Bloom's syndrome, WRN in Werner's syndrome, and RECQL4 in Rothmund-Thomson syndrome. (Adapted from PMID:10893179.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RecQ5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V433)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RecQ5-RA

FBtr0075714

NM_079346

3739

470

RecQ5-RB

FBtr0075715

NM_168591

3412

1058

RecQ5-RC

FBtr0100362

NM_001014584

3664

468

Additional Transcript Data and Comments

Reported size (kB)

3.4 (northern blot)

(Jeong et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RecQ5-PA

FBpp0075457

53.9

470

8.65

FBpp0075458

121.2

1058

9.43

FBpp0099768

53.7

468

8.65

Q59E27

NP_001014584

AAX52745

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1058 (aa); 120 (kD observed); 120 (kD predicted)

(Jeong et al., 2000)

1057, 470, 468 (aa); 121, 54 (kD predicted)

(Sekelsky et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RecQ5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RecQ5_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.83

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 2 -- 5

organism | ubiquitous

(Jeong et al., 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Jeong et al., 2000)

adult stage & oogenesis stage S10

nurse cell

(Jeong et al., 2000)

adult stage oogenesis stage S11 -- S12

oocyte

(Jeong et al., 2000)

Additional Descriptive Data

RecQ5 transcripts are detected throughout development on northern blots with the highest levels in ovaries and early embryos. Transcripts are found to be uniformly distributed in syncytial blastoderm embryos and localized to the periphery of the cellular blastoderm embryo by in situ hybridization. During oogenesis, RecQ5 transcripts are detectable mainly in nurse cells of stage 10 egg chambers and accumulate in the oocyte in stages 11 and 12.

(Jeong et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Sekelsky et al., 1999)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RecQ5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RecQ5

View exonic expression by tissue for Dmel\RecQ5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39594/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027375

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4879

Flygut - An atlas of the Drosophila adult midgut

FBgn0027375

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RecQ5

Transgenic constructs containing regulatory region of RecQ5

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6124

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RecQ5^GD5051

viable, with Scer\GAL4^Mef2.PR

RecQ5^GD5051

viable, with Scer\GAL4^pnr-MD237

RecQ5^GD5051

viable, with Scer\GAL4^tin.CΔ4

RecQ5^GD5051

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal developmental rate

RecQ5⁵

abnormal DNA repair

RecQ5⁵

abnormal mitotic cell cycle | maternal effect

abnormal mitotic cell cycle | maternal effect (with RecQ5^D1)

RecQ5^D2

abnormal mitotic cell cycle | maternal effect (with RecQ5^D2)

RecQ5^D1

radiation sensitive (with Df(3L)fz-D21)

RecQ5^D1

radiation sensitive | third instar larval stage

RecQ5⁵

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

RecQ5^GD5051

Phenotype manifest in

Allele

centrosome | maternal effect

RecQ5^D1

centrosome | maternal effect (with RecQ5^D1)

RecQ5^D2

centrosome | maternal effect (with RecQ5^D2)

RecQ5^D1

embryo | maternal effect

embryo | maternal effect (with RecQ5^D1)

RecQ5^D2

embryo | maternal effect (with RecQ5^D2)

RecQ5^D1

eye, with Scer\GAL4^GMR.PF

RecQ5^UAS.cNa

interommatidial bristle, with Scer\GAL4^GMR.PF

RecQ5^UAS.cNa

nucleus | maternal effect

nucleus | maternal effect (with RecQ5^D1)

RecQ5^D2

nucleus | maternal effect (with RecQ5^D2)

RecQ5^D1

ommatidial precursor cluster, with Scer\GAL4^GMR.PF

RecQ5^UAS.cNa

testis | adult stage (with RecQ5^D1)

RecQ5^D2

testis | adult stage (with RecQ5^D2)

RecQ5^D1

waste bag (with RecQ5^D1)

RecQ5^D2

waste bag (with RecQ5^D2)

RecQ5^D1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\RECQL5

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Recql5

11 of 14

Yes

Rnor\Recql4

3 of 14

Rnor\Recql

3 of 14

Rnor\Wrn

3 of 14

Yes

Rnor\Blm

2 of 14

Rnor\Ddx20

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Recql5

11 of 14

Yes

Mmus\Blm

3 of 14

Mmus\Recql4

3 of 14

Mmus\Wrn

3 of 14

Yes

Mmus\Recql

2 of 14

Mmus\Ddx20

1 of 14

Mmus\Ddx42

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\recql5

6 of 13

Yes

Xtro\blm

2 of 13

Xtro\wrn

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (6)

Drer\recql5

10 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\ddx20

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\rcq-5

12 of 14

Yes

Cele\him-6

3 of 14

Cele\wrn-1

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP001255

10 of 12

Yes

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (22)

Atha\RecQl3

8 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\SGS1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Scer\PRP5

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\tlh1

3 of 12

Yes

Spom\tlh2

3 of 12

Yes

Spom\rqh1

2 of 12

Spom\SPAC23A1.19c

1 of 12

Yes

Spom\SPAC212.06c

1 of 12

Escherichia coli (enterobacterium) (1)

Ecol\recQ

4 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RecQ5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

Blm

5 of 13

RecQ4

5 of 13

abs

1 of 13

ais

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

WRN; WRN RecQ like helicase

model of Werner syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

RecQ5^GS9658

ameliorates neurodegenerative disease

modeled by Hsap\ATXN1^82Q.UAS

(Barclay et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RECQL5; RecQ like helicase 5

11 of 14

603781

BLM; BLM RecQ like helicase

3 of 14

604610

BLOOM SYNDROME; BLM

Bloom syndrome

RECQL4; RecQ like helicase 4

3 of 14

603780

RECQL; RecQ like helicase

3 of 14

600537

RECON PROGEROID SYNDROME; RECON

WRN; WRN RecQ like helicase

3 of 14

604611

WERNER SYNDROME; WRN

Werner syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RecQ5 - spn-A

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, two hybrid

(Maruyama et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

RecQ5

suppressible

lok

(Sakurai et al., 2011)

RecQ5

enhanceable

mei-41

(Nakayama et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64924

DroID - A comprehensive database of gene and protein interactions.

FBgn0027375

MIST (protein-protein) - An integrated Molecular Interaction Database

39594

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70E5-70E5

Sequence location

3L:14,628,160..14,632,077 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70E5-70E5

Limits computationally determined from genome sequence between P{PZ}Mpcp⁰⁰⁵⁶⁴ and P{PZ}l(3)rO220^rO220

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70D6-70E2

(determined by in situ hybridisation)

(Jeong et al., 2000)

70E1-70E2

(Jeong, 1999.8.13, Jeong, 1999.8.13)

70E1-70E4

(Sekelsky, 1999.3.10)

70D-70E

(determined by in situ hybridisation)

(Jeong, 1998.3.12)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

12615

w¹¹¹⁸; P{GT1}RecQ5^BG01967

32466

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00466}attP2

Kyoto

108884

w¹¹¹⁸; P{GT1}RecQ5^BG01967

124047

w¹¹¹⁸; P{RS3}RecQ5^CB-6322-3

201957

y¹ w^67c23; P{GSV6}RecQ5^GS9658/TM3, Sb¹ Ser¹

NIG-Fly

HMS00466

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00466}attP2

VDRC

v13363

w¹¹¹⁸; P{GD5051}v13363

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (42)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027375

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027375

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jeong et al., 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2R+-MT::Cas9 : The following stable knockout S2 cell lines were created: Arip4KO (CG4049), ldsKO, domKO, RecQ5KO, brmKO, and Mi-2KO.
(Deger et al., 2022)

Other Comments

DNA damage caused by methyl-methanesulfonate (MMS) increases the level of RecQ5 in S2 cells. This overexpression perturbs cell-cycle progression under the condition of DNA damage.

(Nakayama et al., 2006)

The RecQ5 protein is a ssDNA-stimulated ATPase and an ATP-dependent DNA helicase. It is also a ssDNA-dependent GTPase, and GTP binding stimulates the ATP-dependent DNA helicase activity of the protein.

(Kawasaki et al., 2002)

RecQ5 expression is developmentally regulated and the DNA helicase activity of RecQ5 might be involved in the DNA metabolism of early embryos.

(Jeong et al., 2000)

Isolated a cDNA clone, homologous to E.coli recQ, from a D.melanogaster library.

(Jeong et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: RecQ5 anon- EST:Posey293

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: RecQ5 CG4879

(Bayraktaroglu, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG4879

(Hosono et al., 2015, Ni et al., 2010.12.1, Molnar et al., 2006)

DQ1

(Kawasaki and Shibata, 2000, Jeong et al., 1998)

Dm RECQ5/QE

(Kawasaki et al., 2003)

DmRECQ5

(Ozsoy et al., 2003)

Dq1

(Kawasaki et al., 1999)

(Jeong, 1998.3.12)

RECQ5

(Nakayama et al., 2006, Ozsoy et al., 2001)

RECQ5/QE

(Nakayama et al., 2006, Kawasaki et al., 2002)

RECQE

(Jeong et al., 2000, Kawasaki and Shibata, 2000, Jeong, 1999.8.13, Jeong, 1999.8.13)

RecQ5

(Pennemann et al., 2021, Barclay et al., 2014, Sakurai et al., 2014, Sakurai et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Maruyama et al., 2012, Sakurai et al., 2011, Wasbrough et al., 2010, Nakayama et al., 2009, Bakal et al., 2007, Molnar et al., 2006, Nakayama et al., 2006)

anon-EST:Posey293

dRecQ5

(Chen et al., 2010)

dmRecQ5b

(Machwe et al., 2005)

recq5

(Sakurai et al., 2014)

Name Synonyms

Drosophila homolog of RecQ

(Jeong et al., 1998)

RecQ5 helicase

homolog of RecQ

(Jeong et al., 1998)

Secondary FlyBase IDs

FBgn0024312
FBgn0027689

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 65 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39594

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V433

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V433

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39594/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027375

FlyMine - An integrated database for Drosophila genomics

FBgn0027375

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4879

MARRVEL_MODEL - MARRVEL (model organism gene)

39594

Linkouts

BioGRID - A database of protein and genetic interactions.

64924

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027375

DroID - A comprehensive database of gene and protein interactions.

FBgn0027375

DRSC - Results frm RNAi screens

FBgn0027375

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RecQ5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027375

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4879

Flygut - An atlas of the Drosophila adult midgut

FBgn0027375

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033312

MIST (protein-protein) - An integrated Molecular Interaction Database

39594

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

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