FlyBase Gene Report: Dmel\bgm

General Information

Symbol

Dmel\bgm

Species

D. melanogaster

Name

bubblegum

Annotation Symbol

CG4501

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027348

Gene Model Status

Current

Stock Availability

14 publicly available

Enzyme Name (EC)

long-chain-fatty-acid--CoA ligase (6.2.1.3)

Gene Summary

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10373116, PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104). (UniProt, Q9V3S9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

BG:DS01514.2

Key Links

Genomic Location

Cytogenetic map

34F1-34F1

Sequence location

2L:14,013,004..14,019,328 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14013004..14019328

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables long-chain fatty acid-CoA ligase activity

inferred from direct assay

(Sivachenko et al., 2016)

inferred from mutant phenotype

(Min and Benzer, 1999)

enables protein binding

inferred from physical interaction with UniProtKB:Q9W3N0

(Ugrankar et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables fatty acid ligase activity

traceable author statement

(Watkins et al., 2007)

enables long-chain fatty acid-CoA ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN000645564

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in fatty acid metabolic process

inferred from mutant phenotype

(Sivachenko et al., 2016)

involved_in long-chain fatty acid metabolic process

inferred from mutant phenotype

(Gordon et al., 2018, Min and Benzer, 1999)

involved_in neuron cellular homeostasis

inferred from mutant phenotype

(Sivachenko et al., 2016)

involved_in positive regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Thimgan et al., 2015)

involved_in response to endoplasmic reticulum stress

inferred from high throughput mutant phenotype

(Chow et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in fatty acid biosynthetic process

traceable author statement

(Watkins et al., 2007)

involved_in long-chain fatty acid biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000645564

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000645564

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ACYL-COA SYNTHETASES

Protein Family (UniProt)

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. (Q9V3S9)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

long-chain fatty acid-CoA ligase activity

a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate (6.2.1.3)

RHEA 15421:

Summaries

Gene Group (FlyBase)

ACYL-COA SYNTHETASES -: Acyl-coenzyme A (CoA) synthetases catalyze the "activation" of fatty acids by their thioesterification to CoA. This is the initial reaction in fatty acid metabolism, allowing their participation in many fundamental anabolic and catabolic pathways. (Adapted from FBrf0237395).

Protein Function (UniProtKB)

(UniProt, Q9V3S9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\bgm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3S9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.42

Gene model reviewed during 5.57

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

bgm-RA

FBtr0080590

NM_079959

2501

666

bgm-RC

FBtr0346624

NM_001298994

2464

666

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

bgm-PA

FBpp0080167

73.6

666

8.38

FBpp0312204

73.6

666

8.38

Q9V3S9

NP_001285923

AHN54437

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

666 aa isoforms: bgm-PA, bgm-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bgm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bgm_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.84

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

fat body primordium

Comment: reported as fat body specific anlage

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval fat body

(Fisher et al., 2012)

adult stage | male

adult fat body

(Ellis and Carney, 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bgm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bgm

View exonic expression by tissue for Dmel\bgm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027348

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44117/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027348

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027348

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027348

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4501

Flygut - An atlas of the Drosophila adult midgut

FBgn0027348

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\bgm

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bgm

Transgenic constructs containing regulatory region of bgm

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel8032

(Ryder, 2004.4.26)

Gene not disrupted in

Df(2L)b84h50

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

bgm^GD11331

lethal | pupal stage, with Scer\GAL4^pnr-MD237

bgm^GD11331

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

bgm^GD11331

viable

viable, with Scer\GAL4^tin.CΔ4

bgm^GD11331

Sterility

Allele

fertile

bgm^EY03176

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

bgm¹

abnormal neuroanatomy

bgm¹

abnormal neuroanatomy | adult stage

bgm¹

abnormal neuroanatomy | adult stage (with Df(2L)b87e25)

bgm¹

abnormal sleep

bgm¹

abnormal sleep, with Scer\GAL4^Act.PU

bgm^EY03176

abnormal visual behavior | recessive

bgm¹

decreased cell number | adult stage

bgm¹

increased speed of aging | recessive

bgm¹

visible, with Scer\GAL4^pnr-MD237

bgm^GD11331

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

bgm^JF03054

Phenotype manifest in

Allele

adult optic lobe

bgm¹

basement membrane | adult stage

bgm¹

embryonic/larval gut | larval stage

bgm¹

eye, with Scer\GAL4^eya.enh1+E+2

bgm^JF03054

lamina

bgm¹

lamina (with Df(2L)b87e25)

bgm¹

lamina monopolar neuron

bgm¹

mesothoracic tergum, with Scer\GAL4^pnr-MD237

bgm^GD11331

ommatidium

bgm¹

photoreceptor cell & axon

bgm¹

pigment cell

bgm¹

retina

bgm¹

retina & cell body

bgm¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (10)

Hsap\ACSBG1

13 of 14

Yes

Hsap\ACSBG2

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\Acsbg1

13 of 14

Yes

Rnor\Acsbg2

13 of 14

Yes

Rnor\LOC316124

6 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Acsbg2

13 of 14

Yes

Mmus\Acsbg1

12 of 14

Yes

Mmus\Acsbg3

7 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\acsbg2

7 of 13

Yes

Xtro\acsbg1

6 of 13

Yes

Xtro\LOC100494473

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (12)

Drer\acsbg1

13 of 14

Yes

Drer\acsbg2

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\acs-15

5 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP008596

11 of 12

Yes

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (15)

Atha\AAE15

3 of 13

Yes

Atha\AAE16

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\FAA1

2 of 13

Yes

Scer\FAA2

2 of 13

Yes

Scer\FAA3

2 of 13

Yes

Scer\FAA4

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\lcf1

2 of 12

Yes

Spom\lcf2

2 of 12

Yes

Escherichia coli (enterobacterium) (2)

Ecol\menE

2 of 11

Yes

Ecol\caiC

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:bgm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

hll

12 of 13

5 of 13

5 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

adrenoleukodystrophy (postulated), ACSBG-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

bgm¹

model of adrenoleukodystrophy

CEA with hll¹

(Sivachenko et al., 2016)

CEA

(Gordon et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACSBG1; acyl-CoA synthetase bubblegum family member 1

13 of 14

614362

ACSBG2; acyl-CoA synthetase bubblegum family member 2

13 of 14

614363

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bgm - snz

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Ugrankar et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bgm

enhanceable

hll

(Sivachenko et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hll

enhanceable

bgm

(Sivachenko et al., 2016)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0027348

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of very long-chain fatty acyl-CoAs

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of very long-chain fatty acyl-CoAs

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34F1-34F1

Sequence location

2L:14,013,004..14,019,328 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34F1-34F1

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34F1-34F2

(determined by in situ hybridisation)

(Ashburner et al., 1999, Spradling et al., 1999)

34F1-34F2

(Min and Benzer, 1999)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28120

w^*; P{lacW}bgm¹

12755

w¹¹¹⁸; P{GT1}bgm^BG01356

59375

y¹ w^*; Mi{MIC}bgm^MI14249

19994

y¹ w^67c23; P{EPgy2}bgm^EY03176

28639

y¹ v¹; P{TRiP.JF03054}attP2/TM3, Sb¹

79335

y¹ w^*; TI{CRIMIC.TG4.2}bgm^{CR00874-TG4.2}/SM6a

68085

y¹ sc^* v¹ sev²¹; P{TOE.GS00482}attP40

55918

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04204}attP2

Korea

10898

P{EP}bgm^G2351

Kyoto

102726

y¹ w^67c23 ; P{lacW}bgm^k09909 / CyO

VDRC

v105635

P{KK101145}VIE-260B

v34853

w¹¹¹⁸; P{GD11331}v34853

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (56)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM14009

Other clones

FI05443

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027348

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027348

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: BG:DS01514.2 CG4501

(Kodira, 1999.11)

Nomenclature comments

Etymology

The appellation bubblegum refers to the bubbly appearance of the lamina in the mutant. bgm mutant flies provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment of ALD.

(Min and Benzer, 1999)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

2a9hom

(Ashburner et al., 1999.10.12)

BG:DS01514.2

(Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

BG:DS0514.2

(Ashburner et al., 1999)

Bgm

(Zhao et al., 2012)

CG4501

(Ibaraki et al., 2021, Hosono et al., 2015, Sun et al., 2014, Ellis and Carney, 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Bhutkar et al., 2008, Watkins et al., 2007, Klebes et al., 2005, Oba et al., 2004)

Name Synonyms

Bubblegum

(Faust et al., 2012)

bubblegum

(Newell et al., 2020, Riahi et al., 2019, Thimgan et al., 2018, Sivachenko et al., 2016, Ellis and Carney, 2010, Kühnlein, 2010, Pospisilik et al., 2010, Berkaeva et al., 2009, Watkins et al., 2007, Morozova et al., 2006, Sivatchenko and Letsou, 2006, Barinaga, 1999, Min and Benzer, 1999)

Secondary FlyBase IDs

FBgn0027881
FBgn0028908

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44117

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3S9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3S9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

B5RIV0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3S9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027348

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44117/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027348

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027348

FlyMine - An integrated database for Drosophila genomics

FBgn0027348

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4501

MARRVEL_MODEL - MARRVEL (model organism gene)

44117

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027348

DroID - A comprehensive database of gene and protein interactions.

FBgn0027348

DRSC - Results frm RNAi screens

FBgn0027348

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bgm_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027348

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027348

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4501

Flygut - An atlas of the Drosophila adult midgut

FBgn0027348

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0027348

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004625

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of very long-chain fatty acyl-CoAs

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of very long-chain fatty acyl-CoAs

References (104)

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