Succinate dehydrogenase B, succinate dehydrogenase, SDH
Please see the JBrowse view of Dmel\SdhB for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
1.3 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
297 (aa)
Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SdhB using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
SdhB transcripts are detected in RNA from larvae and adults on northern blots. In adults they are most abundant in the thorax and are barely detectable in the abdomen.
JBrowse - Visual display of RNA-Seq signals
View Dmel\SdhB in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
SdhB is critical in preventing electron leakage from complex II, so that mutant animals suffer from increased oxidative stress and, as a result, are highly sensitive to oxygen and die rapidly.
Functionality of SdhB is demonstrated by showing translational regulation in vivo in response to iron treatment.
Isolated from a genomic library, using a human Ip (iron-sulphur protein subunit of succinate dehydrogenase) cDNA as a probe, under low stringency conditions.
SdhB has been cloned and characterised.
The partial cDNA reported previously for SdhB (FBrf0050820) does not correspond to SdhB and probably arose from a mix-up or contamination.