EC3, EG:BACR37P7.7 , l(1)EC3, l(1)1Ag
nuclear respiratory factor-1 transcription factor - regulates synaptic growth - regulates spatio-temporal coordination of cell cycle exit, fusion and differentiation of adult muscle precursors
Please see the JBrowse view of Dmel\ewg for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.41
Unconventional translation start (CUG) postulated; FBrf0059052.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
6.0, 5.2, 5.1, 4.3, 3.7 (northern blot)
733 (aa); 116 (kD observed)
Homodimer. Binds DNA as a dimer (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ewg using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
This transcript is enriched in adult head over adult body.
Comment: 10-36 hr APF
Comment: reference states 10-36 hr APF
JBrowse - Visual display of RNA-Seq signals
View Dmel\ewg in JBrowse1-0
1-0.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Expression in the nervous system can rescue the embryonic lethality of ewg mutants but not the adult muscle defects. Expression from a heat shock promoter can restore IFM defects.
Protein encoded by the ewg open reading frame is sufficient to provide both the embryonic function and the requirement for the formation of indirect flight muscles.
Viable alleles cause wings to be held upright; wing posture phenotype shows incomplete penetrance. Dorso-ventral flight muscles often absent, especially when the mutation is heterozygous with a deficiency. Ultrastructure of tergal depressor of trochanter jump muscle normal. Flies hemizygous for lethal alleles die either just prior to hatching of the larva from the egg or immediately thereafter; mosaic analysis of certain lethal alleles suggests primary defect in developing muscles.
Fate mapping of ewg mutants suggests their primary site of action maps to the ventral thoracic region of the blastoderm.
Source for identity of: ewg CG3114
Source for identity of: ewg NRF-1
