tMAC
regulator of chromatin structure - a 'meiotic arrest' gene required for transcription of key G2-M cell cycle control genes and of spermatid differentiation genes -mfunction in leg disc regeneration
Please see the JBrowse view of Dmel\aly for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aly using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\aly in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
aly may regulate cell cycle progression and terminal differentiation during male gametogenesis by regulating chromatin conformation in primary spermatocytes.
Wild type function of aly is required for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid differentiation.
The phenotype of mutants is strikingly similar to the histopathological features of meiosis I maturation arrest infertility in human males, suggesting that the control point may be conserved from flies to man.
aly is required for both the progression of the male meiotic cell cycle and the onset of postmeiotic differentiation.
Mutations of aly affect the morphology and behaviour of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts.
Source for identity of aly CG2075 was sequence comparison ( date:000414 ).
Source for identity of: aly CG2075