Sgs-1, Sgs
Please see the JBrowse view of Dmel\Sgs1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.44
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sgs1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Sgs1 transcripts are expressed exclusively in salivary glands of third instar larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sgs1 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Sgs1 encodes the most slowly migrating of the salivary-gland glue proteins. One of a group of seven genes encoding proteins that are components of the secretion produced by the larval salivary glands during the third instar for the purpose of attaching the larva to the substrate preparative to pupariation.
Cessation of Sgs1 transcription and puff regression are ecdysterone-dependent.
Initiation of transcription of Sgs1, but not of intermolt-puff formation seems to depend on the presence of suitable levels of ecdysterone in early third instar larvae.
Synthesis of the glue proteins begins about 106 h after egg deposition and ceases abruptly within a few minutes after the glue is released 14 h later.
Initiation of transcription of Sgs1 is coincident with the formation of the intermolt puffs in early to mid third instar.
