l(2)37Cc, lethal (2) 37Cc, Cc
Please see the JBrowse view of Dmel\Phb1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
1.6 (northern blot)
203 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Phb1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Phb1 transcripts are observed on northern blots in RNA from early and late embryos, third instar larvae, and adults. They are most abundant at the late embryo stage.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Phb1 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Located between coordinates +5.8 and +7.4.
Biochemical characterization of the l(2)37Cc gene product suggest the protein is associated with a mitochondrial membrane.
l(2)37Cc has a role in cuticle formation.
Dot matrix analysis demonstrates there is very little sequence homology between Ddc or amd, and l(2)37Cc or CG10561 transcripts, nor is there any relationship between l(2)37Cc or CG10561 transcripts.
Complementation analysis of the 7.6kb PstI fragment demonstrates this fragment carries the Ddc gene alone.
Many different complementing heteroallelic genotypes exhibit opaque wings, often incompletely expanded, moderate Minute-like bristles and a lighter tan body color.
Source for merge of: l(2)37Cc CG10691
Source for identity of: Phb1 l(2)37Cc