FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: OXOADIPATE DEHYDROGENASE COMPLEX
Open Close
General Information
Name
OXOADIPATE DEHYDROGENASE COMPLEX
Species
D. melanogaster
Symbol
OADHC
FlyBase ID
FBgg0001961
Date last reviewed
2024-03-06
Number of members
3
Description
Description
A multi-enzyme complex that catalyzes the oxidative decarboxylation of 2-oxoadipate to glutaryl-CoA, thereby acting in the final step of lysine and tryptophan catabolism within mitochondria. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: 2-oxoadipate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The 2-oxoadipate dehydrogenase (E1) component is analogous to the oxoglutarate dehydrogenase (E1) component of the OGDH complex, while the E2 and E3 components of the two complexes are identical. (Adapted from PMID:29191460, PMID:32695416, PMID:33045952.]
Notes on Group
Source Material
The OXOADIPATE DEHYDROGENASE COMPLEX Gene Group has been compiled using the following publication(s): Marygold, 2024 and Marygold, 2024.1.15 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Dihydrolipoamide dehydrogenase
diaphorase-2'
Dihydrolipoamide S-succinyltransferase
Oxoadipate dehydrogenase
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
OADHC
OXOADIPATE DEHYDROGENASE COMPLEX
Secondary FlyBase ID(s)
References (3)