Gene Group - Macromolecular Complex: OXOGLUTARATE DEHYDROGENASE COMPLEX

General Information

Name

OXOGLUTARATE DEHYDROGENASE COMPLEX - OGDH1 VARIANT

Species

D. melanogaster

Symbol

OGDH-C

FlyBase ID

FBgg0001864

Date last reviewed

2024-03-06

Number of members

Description

The oxoglutarate dehydrogenase complex catalyses the conversion of 2-oxoglutarate into succinyl-CoA in the tricarboxylic acid cycle, thereby fulfilling crucial functions in mitochondria by providing metabolites and reduced electron carriers for oxidative phosphorylation. It is a giant enzyme cluster composed of multiple copies of three subunits. The dihydrolipoyllysine-residue succinyltransferase subunit (DLST, also known as E2) serves as a structural core unit. The OGDH (also known as E1) and dihydrolipoyl dehydrogenase (DLD, also known as E3) subunits sit in the periphery of the E2 core. The OGDH subunit recognizes the 2-oxoglutarate substrate and provides specificity to the complex. (Adapted from FBrf0256925.)

Notes on Group

CG44242 encodes a protein with the InterPro signature 'Alpha-ketoglutarate dehydrogenase component 4/YMR-31' (IPR020373), which identifies a protein (known as Kgd4/Ymr31/MRPS36) that functions as a molecular adaptor to form a stable oxoglutarate dehydrogenase complex. However, it's unclear if CG44242 is the true ortholog and/or has this function.

The OGDH subunit is encoded by two paralogous genes in D. melanogaster: Ogdh1 is expressed ubiquitously whereas Ogdh2 is testis-specific.

Source Material

The OXOGLUTARATE DEHYDROGENASE COMPLEX - OGDH1 VARIANT Gene Group has been compiled using the following publication(s): Marygold, 2024, Marygold, 2024.1.15, and González Morales et al., 2023 .

Key Gene Ontology (GO) terms

Molecular Function

oxoglutarate dehydrogenase (NAD+) activity

Biological Process

tricarboxylic acid cycle

Cellular Component

oxoglutarate dehydrogenase complex

Enzymatic activity

Enzyme name (EC)

2-oxoglutarate dehydrogenase system (1.2.1.105)

Related Gene Groups

Parent group(s)