FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: NUCLEOSOME REMODELING DEACETYLASE COMPLEX
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General Information
Name
NUCLEOSOME REMODELING DEACETYLASE COMPLEX
Species
D. melanogaster
Symbol
NURD
FlyBase ID
FBgg0000275
Date last reviewed
2023-08-08
Number of members
8
Description
Description
The nucleosome remodelling and deacetylase (NuRD) complex couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. (Adapted from FBrf0228973 and FBrf0228920).
Notes on Group

FBrf0212010 identifies MEP-1 and CDK2AP1 as Drosophila NURD complex subunits, and are included in this list. ttk, which is not included, binds chromatin and recruits the complex.

Source Material
The NUCLEOSOME REMODELING DEACETYLASE COMPLEX Gene Group has been compiled using the following publication(s): Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, and Clapier and Cairns, 2009 .
Key Gene Ontology (GO) terms
Molecular Function
ATP hydrolysis activity
histone deacetylase activity
Biological Process
chromatin remodeling
post-translational protein modification
Cellular Component
NuRD complex
Enzymatic activity
Enzyme name (EC)
histone deacetylase (3.5.1.98)
Related Gene Groups
Parent group(s)
CHROMATIN MODIFYING COMPLEXES
CHROMATIN REMODELING COMPLEXES (ATP-DEPENDENT)
TRITHORAX GROUP COMPLEXES
Members (8)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Caf1-55
Chromatin assembly factor 1, p55 subunit
p55, Caf1, NURF, NURF55, NURF-55
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
CDK2AP1
CDK2-associated protein 1
(Zhang et al., 2016, Reddy et al., 2010)
HDAC1
Histone deacetylase 1
Rpd3, dHDAC1, dRPD3, HDAC, Su(var)326
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
MBD-like
Methyl-CpG binding domain protein-like
dMBD2/3, MBD2/3, MBD3, MBD2
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
MEP-1
MEP-1
(Reddy et al., 2010)
Mi-2
Mi-2
dMi-2, Pha, dMi2, l(3)S085401, PHD-containing ATPase
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
MTA1-like
Metastasis associated 1-like
MTA-like, dMTA1-like, MTA1, MTA, dMTA
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
simj
simjang
p66, l(3)01814, dp66
(Zhang et al., 2016, Schuettengruber et al., 2011, Reddy et al., 2010, Clapier and Cairns, 2009)
External Data
Synonyms and Secondary IDs
Synonym(s)
NURD
NUCLEOSOME REMODELING DEACETYLASE COMPLEX
Mi2-nucleosome remodelling and deacetylase
Mi-2/NuRD complex
Mi2-NURD
dNuRD
Secondary FlyBase ID(s)
References (5)